YRC Public Data Repository - Protein Structure Prediction

Protein:	THIE_ECOLI
Organism:	Escherichia coli
Length:	211 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THIE_ECOLI.

Description	E-value	Query Range	Subject Range
THIE_CALS8 - Thiamine-phosphate synthase OS=Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) G...	178.0	[0..1]	[208..1]
gi\|45683800, gi\|... - gi\|69276384\|ref\|ZP_00611978.1\| Thiamine monophosphate synthase [Mesorhizobium sp. BNC1], gi\|68192290...	172.0	[0..9]	[211..1]
THIE_PHOLL - Thiamine-phosphate pyrophosphorylase OS=Photorhabdus luminescens subsp. laumondii GN=thiE PE=3 SV=1 THIE_PHOLL - Thiamine-phosphate synthase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105...	172.0	[0..1]	[207..4]
THIE_SALPK - Thiamine-phosphate synthase OS=Salmonella paratyphi A (strain AKU_12601) GN=thiE PE=3 SV=1 THIE_SALPA - Thiamine-phosphate synthase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=thiE PE=3 SV=1 THIE_SALPA - Thiamine-phosphate synthase OS=Salmonella paratyphi A GN=thiE PE=3 SV=1	171.0	[0..1]	[211..1]
gi\|77957006 - gi\|77957006\|ref\|ZP_00821075.1\| COG0352: Thiamine monophosphate synthase [Yersinia bercovieri ATCC 43...	171.0	[0..1]	[207..1]
gi\|78044820, gi\|... - gi\|78044820\|ref\|YP_359600.1\| thiamine-phosphate pyrophosphorylase [Carboxydothermus hydrogenoformans...	171.0	[0..12]	[211..158]
gi\|56459875, gi\|... - gi\|56459875\|ref\|YP_155156.1\| thiamine monophosphate synthase [Idiomarina loihiensis L2TR], gi\|561788...	171.0	[0..6]	[208..286]
gi\|77960646 - gi\|77960646\|ref\|ZP_00824508.1\| COG0352: Thiamine monophosphate synthase [Yersinia mollaretii ATCC 43...	170.0	[0..1]	[207..1]
THIE_YERPS - Thiamine-phosphate synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=thiE PE=3 ... THIE_YERPS - Thiamine-phosphate synthase OS=Yersinia pseudotuberculosis GN=thiE PE=3 SV=1 THIE_YERP3 - Thiamine-phosphate synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=thiE P...	170.0	[0..1]	[207..1]
THIE_YERPE - Thiamine-phosphate synthase OS=Yersinia pestis GN=thiE PE=3 SV=1 gi\|153997226, gi... - gi\|153997226\|ref\|ZP_02022333.1\| thiamine-phosphate pyrophosphorylase [Yersinia pestis CA88-4125], gi... gi\|115349356, gi... - gi\|218930745\|ref\|YP_002348620.1\| thiamine-phosphate pyrophosphorylase [Yersinia pestis CO92], gi\|161... THIE_YERPP - Thiamine-phosphate synthase OS=Yersinia pestis (strain Pestoides F) GN=thiE PE=3 SV=2 THIE_YERPN - Thiamine-phosphate synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=thiE PE=3 SV=2 THIE_YERPA - Thiamine-phosphate synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=thiE PE=3 SV=2 gi\|229837487, gi... - gi\|229837487\|ref\|ZP_04457649.1\| thiamin phosphate synthase (thiamin phosphate pyrophosphorylase) [Ye... gi\|229695788, gi... - gi\|229839422\|ref\|ZP_04459581.1\| thiamin phosphate synthase (thiamin phosphate pyrophosphorylase) [Ye... gi\|229899984, gi... - gi\|229899984\|ref\|ZP_04515124.1\| thiamin phosphate synthase (thiamin phosphate pyrophosphorylase) [Ye...	169.0	[0..1]	[207..1]

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Predicted Domain #1

Region A:
Residues: [1-211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQPDFPPVP FRSGLYPVVD SVQWIERLLD AGVRTLQLRI KDRRDEEVEA DVVAAIALGR  60
   61 RYNARLFIND YWRLAIKHQA YGVHLGQEDL QATDLNAIRA AGLRLGVSTH DDMEIDVALA 120
  121 ARPSYIALGH VFPTQTKQMP SAPQGLEQLA RHVERLADYP TVAIGGISLA RAPAVIATGV 180
  181 GSIAVVSAIT QAADWRLATA QLLEIAGVGD E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.154902
Match:	1g4tA
Description:	Thiamin phosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thiamin-phosphate diphosphorylase activity	6.04450222340788	bayes_pls_golite062009
catalytic activity	2.31352397210218	bayes_pls_golite062009
phosphomethylpyrimidine kinase activity	2.16632642989285	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.16976945211093	bayes_pls_golite062009
transferase activity	1.16478613213801	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.63318404518052	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: