YRC Public Data Repository - Protein Structure Prediction

Protein:	ARLY_ECOLI
Organism:	Escherichia coli
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARLY_ECOLI.

Description	E-value	Query Range	Subject Range
ARLY_BACWK - Argininosuccinate lyase OS=Bacillus weihenstephanensis (strain KBAB4) GN=argH PE=3 SV=1	508.0	[0..2]	[455..3]
ARLY_BACCN - Argininosuccinate lyase OS=Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98...	508.0	[0..2]	[457..3]
ARLY_GEOUR - Argininosuccinate lyase OS=Geobacter uraniireducens (strain Rf4) GN=argH PE=3 SV=1	507.0	[0..2]	[453..5]
ARLY_GEODF - Argininosuccinate lyase OS=Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32) GN=argH PE=3 S...	506.0	[0..2]	[454..5]
ARLY_PELPD - Argininosuccinate lyase OS=Pelobacter propionicus (strain DSM 2379) GN=argH PE=3 SV=1	506.0	[0..2]	[454..5]
ARLY_CLOTH - Argininosuccinate lyase OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NC... gi\|196251693, gi... - gi\|196251693\|ref\|ZP_03150360.1\| argininosuccinate lyase [Clostridium thermocellum DSM 4150], gi\|1961...	506.0	[0..1]	[456..1]
ARLY_PSESM - Argininosuccinate lyase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=argH PE=3 SV=1 ARLY_PSESM - Argininosuccinate lyase OS=Pseudomonas syringae pv. tomato GN=argH PE=3 SV=1	506.0	[0..4]	[457..10]
gi\|11269756 - pir\|\|B81175 argininosuccinate lyase NMB0637 [imported] - Neisseria meningitidis (strain MC58 serogro... ARLY_NEIMB - Argininosuccinate lyase OS=Neisseria meningitidis serogroup B (strain MC58) GN=argH PE=3 SV=1 ARLY_NEIM0 - Argininosuccinate lyase OS=Neisseria meningitidis serogroup C (strain 053442) GN=argH PE=3 SV=1 ARLY_NEIMB - Argininosuccinate lyase OS=Neisseria meningitidis serogroup B GN=argH PE=3 SV=1	506.0	[0..2]	[457..4]
ARLY_BACCR - Argininosuccinate lyase OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCI...	505.0	[0..2]	[455..3]
gi\|84317867, gi\|... - gi\|84317867\|ref\|ZP_00966302.1\| COG0165: Argininosuccinate lyase [Pseudomonas aeruginosa C3719], gi\|2... ARLY_PSEAE - Argininosuccinate lyase OS=Pseudomonas aeruginosa GN=argH PE=3 SV=2 ARLY_PSEAE - Argininosuccinate lyase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 122...	505.0	[0..4]	[457..10]

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Predicted Domain #1

Region A:
Residues: [1-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALWGGRFTQ AADQRFKQFN DSLRFDYRLA EQDIVGSVAW SKALVTVGVL TAEEQAQLEE  60
   61 ALNVLLEDVR ARPQQILESD AEDIHSWVEG KLIDKVGQLG KKLHTGRSRN DQVATDLKLW 120
  121 CKDTVSELLT ANRQLQSALV ETAQNNQDAV MPGYTHLQRA QPVTFAHWCL AYVEMLARDE 180
  181 SRLQDALKRL DVSPLGCGAL AGTAYEIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS 240
  241 AAAIGMVHLS RFAEDLIFFN TGEAGFVELS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ 300
  301 GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MAALVLDGIQ VKRPRCQEAA 360
  361 QQGYANATEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK PLEDLPLSEL QKFSQVIDED 420
  421 VYPILSLQSC LDKRAAKGGV SPQQVAQAIA FAQARLG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	141.0
Match:	1tj7A
Description:	Structure determination and refinement at 2.44 A resolution of Argininosuccinate lyase from E. coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
amidine-lyase activity	3.84281419858187	bayes_pls_golite062009
argininosuccinate lyase activity	3.58328346705456	bayes_pls_golite062009
catalytic activity	2.51282259572665	bayes_pls_golite062009
lyase activity	2.31268471569846	bayes_pls_golite062009
carbon-nitrogen lyase activity	2.2046475419807	bayes_pls_golite062009
fumarate hydratase activity	1.8220456742683	bayes_pls_golite062009
histidine ammonia-lyase activity	0.948129236753279	bayes_pls_golite062009
binding	0.616567403608599	bayes_pls_golite062009
ammonia-lyase activity	0.491229595527877	bayes_pls_golite062009
protein binding	0.110986062813054	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: