YRC Public Data Repository - Protein Structure Prediction

Protein:	AAT_ECOLI
Organism:	Escherichia coli
Length:	396 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AAT_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|42629643 - gi\|42629643\|ref\|ZP_00155189.1\| COG1448: Aspartate/tyrosine/aromatic aminotransferase [Haemophilus in...	333.0	[0..1]	[396..1]
gi\|46133371 - gi\|46133371\|ref\|ZP_00157086.2\| COG1448: Aspartate/tyrosine/aromatic aminotransferase [Haemophilus in...	333.0	[0..1]	[396..1]
gi\|148716303, gi... - gi\|148826143\|ref\|YP_001290896.1\| aromatic amino acid aminotransferase [Haemophilus influenzae PittEE... gi\|145635098, gi... - gi\|145635098\|ref\|ZP_01790804.1\| aromatic-amino-acid aminotransferase [Haemophilus influenzae PittAA]... gi\|144986245, gi... - gi\|145633019\|ref\|ZP_01788751.1\| aspartate aminotransferase [Haemophilus influenzae 3655], gi\|1449862... gi\|48868580, gi\|... - gi\|68249791\|ref\|YP_248903.1\| aromatic amino acid aminotransferase [Haemophilus influenzae 86-028NP],...	333.0	[0..1]	[396..1]
gi\|87121047, gi\|... - gi\|87121047\|ref\|ZP_01076938.1\| aspartate aminotransferase [Marinomonas sp. MED121], gi\|86163539\|gb\|E...	332.0	[0..1]	[396..1]
gi\|36785113, gi\|... - gi\|37525685\|ref\|NP_929029.1\| aromatic amino acid aminotransferase [Photorhabdus luminescens subsp. l...	331.0	[0..1]	[396..1]
gi\|205346904, gi... - gi\|205346904\|gb\|EDZ33535.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar Hada... gi\|168243767, gi... - gi\|205337174\|gb\|EDZ23938.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar Heid... gi\|205327270, gi... - gi\|205327270\|gb\|EDZ14034.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar 4,[5... gi\|205322469, gi... - gi\|205322469\|gb\|EDZ10308.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar Sain... AAT_SALTY - Aspartate aminotransferase OS=Salmonella typhimurium GN=aspC PE=3 SV=1 AAT_SALTY - Aspartate aminotransferase OS=Salmonella typhimurium GN=aspC PE=3 SV=1 AAT_SALTY - Aspartate aminotransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=aspC P... gi\|207856389, gi... - gi\|207856389\|ref\|YP_002243040.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. en... lcl\|NC_016856.1_... - [gene=aspC] [protein=aromatic amino acid aminotransferase] [protein_id=YP_005236718.1] [location=com... gi\|197250328, gi... - gi\|197250328\|ref\|YP_002145916.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar... gi\|194450741, gi... - gi\|194450741\|ref\|YP_002044990.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. en... gi\|194404393, gi... - gi\|194445730\|ref\|YP_002040196.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar... gi\|205341503, gi... - gi\|205341503\|gb\|EDZ28267.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar Welt... gi\|205271986, gi... - gi\|205352205\|ref\|YP_002226006.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. en... gi\|204930064, gi... - gi\|204930064\|ref\|ZP_03221085.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar ... gi\|197936495, gi... - gi\|198241979\|ref\|YP_002214922.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar... gi\|197262193, gi... - gi\|197262193\|ref\|ZP_03162267.1\| aspartate transaminase [Salmonella enterica subsp. enterica serovar ...	331.0	[0..1]	[396..1]
AAT_HAEIN - Aspartate aminotransferase OS=Haemophilus influenzae GN=aspC PE=3 SV=1 AAT_HAEIN - Aspartate aminotransferase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=...	331.0	[0..1]	[396..1]
gi\|16759867 - gi\|16759867\|ref\|NP_455484.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. enteri... gi\|213581706 - gi\|213581706\|ref\|ZP_03363532.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. ent... gi\|213420563 - gi\|213420563\|ref\|ZP_03353629.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. ent... AAT_SALTI - Aspartate aminotransferase OS=Salmonella typhi GN=aspC PE=3 SV=2 gi\|29137990, gi\|... - gi\|29142360\|ref\|NP_805702.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. enteri... gi\|213852477 - gi\|213852477\|ref\|ZP_03382009.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. ent... AAT_SALTI - Aspartate aminotransferase OS=Salmonella typhi GN=aspC PE=3 SV=2 gi\|213160799 - gi\|213160799\|ref\|ZP_03346509.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. ent...	331.0	[0..1]	[396..1]
gi\|197362876, gi... - gi\|197362876\|ref\|YP_002142513.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. en... gi\|56413953, gi\|... - gi\|56413953\|ref\|YP_151028.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. enteri...	330.0	[0..1]	[396..1]
gi\|62127158, gi\|... - gi\|62179525\|ref\|YP_215942.1\| aromatic amino acid aminotransferase [Salmonella enterica subsp. enteri...	330.0	[0..1]	[396..1]

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Predicted Domain #1

Region A:
Residues: [1-396]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFENITAAPA DPILGLADLF RADERPGKIN LGIGVYKDET GKTPVLTSVK KAEQYLLENE  60
   61 TTKNYLGIDG IPEFGRCTQE LLFGKGSALI NDKRARTAQT PGGTGALRVA ADFLAKNTSV 120
  121 KRVWVSNPSW PNHKSVFNSA GLEVREYAYY DAENHTLDFD ALINSLNEAQ AGDVVLFHGC 180
  181 CHNPTGIDPT LEQWQTLAQL SVEKGWLPLF DFAYQGFARG LEEDAEGLRA FAAMHKELIV 240
  241 ASSYSKNFGL YNERVGACTL VAADSETVDR AFSQMKAAIR ANYSNPPAHG ASVVATILSN 300
  301 DALRAIWEQE LTDMRQRIQR MRQLFVNTLQ EKGANRDFSF IIKQNGMFSF SGLTKEQVLR 360
  361 LREEFGVYAV ASGRVNVAGM TPDNMAPLCE AIVAVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.30103
Match:	1aawA
Description:	THE STRUCTURAL BASIS FOR THE ALTERED SUBSTRATE SPECIFICITY OF THE R292D ACTIVE SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM E. COLI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
L-aspartate:2-oxoglutarate aminotransferase activity	5.03677961292867	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
aromatic-amino-acid:2-oxoglutarate aminotransferase activity	0.0916183433120769	bayes_pls_golite062009
cystathionine beta-lyase activity	0.0833010353195099	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: