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View Structure Prediction Details

Protein: UBP12
Organism: Saccharomyces cerevisiae
Length: 1254 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBP12.

Description E-value Query
Range
Subject
Range
UBP12 - Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytopl...
UBP12_YEAST - Ubiquitin carboxyl-terminal hydrolase 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
0.0 [1..1254] [1..1254]
UBP12_SCHPO - Probable ubiquitin carboxyl-terminal hydrolase 12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24...
ubp12 - ubiquitin C-terminal hydrolase Ubp12
0.0 [87..1112] [39..979]
gi|109097590 - gi|109097590|ref|XP_001116737.1| PREDICTED: ubiquitin specific peptidase 15 isoform 2 [Macaca mulatt...
gi|168267398 - gi|168267398|dbj|BAG09755.1| ubiquitin carboxyl-terminal hydrolase 15 [synthetic construct]
gi|119617512, gi... - gi|5814097|gb|AAD52099.1|AF106069_1 deubiquitinating enzyme [Homo sapiens], gi|20521071|dbj|BAA25455...
0.0 [92..839] [2..712]
UBP15_RAT - Ubiquitin carboxyl-terminal hydrolase 15 OS=Rattus norvegicus GN=Usp15 PE=1 SV=1
0.0 [92..839] [2..712]
UBP15_MOUSE - Ubiquitin carboxyl-terminal hydrolase 15 OS=Mus musculus GN=Usp15 PE=1 SV=1
0.0 [92..839] [2..741]
gi|5669678 - gi|5669678|gb|AAD46422.1|AF105715_1 ubiquitous nuclear protein [Gallus gallus]
0.0 [92..875] [2..746]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSSDVSSRE CSLVYNEDPD FTDGTTPCDR LGVDLMNVLD DKDEIKQESV PVSDREIEDT  60
   61 ESDASAVSSF ASANELIAEP HAASETNLGT 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.345 a.4.1 Homeodomain-like
View Download 0.308 d.109.1 Actin depolymerizing proteins
View Download 0.306 a.64.1 Saposin
View Download 0.491 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.491 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.345 a.4.1 Homeodomain-like
View Download 0.308 d.109.1 Actin depolymerizing proteins
View Download 0.306 a.64.1 Saposin
View Download 0.294 a.64.1 Saposin
View Download 0.292 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.274 a.2.3 Chaperone J-domain
View Download 0.274 a.4.5 "Winged helix" DNA-binding domain
View Download 0.215 a.3.1 Cytochrome c
View Download 0.211 a.1.1 Globin-like
View Download 0.200 a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #2
Region A:
Residues: [91-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGQDGRNVLE QQRDVVARLI EENKETQKEG DKVCIVPKVW YDKFFDPDVT DPEDIGPINT  60
   61 RMICRDFENF VLEDYNRCPY LSIAEPVFNF LSEIYGMTSG SYPVVTNLVI NQTTGELETE 120
  121 YNKWFFRLHY LTEKQDGRKR RHGQDDSIMY LSMSALNLVR DLVEKSMNLF FEKADHLDVN 180
  181 AVDFKIWFVS EGSDIATDSN VSTFLNSSYE ITPLQFLELP IKKLLIPDMF ENRLDKITSN 240
  241 PSDL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.65407544330213 bayes_pls_golite062009
protein binding 0.63630897700088 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [335-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIEIKPIEGN HHWPSNYFAY NKLEPASGTT GLVNLGNTCY MNSALQCLVH IPQLRDYFLY  60
   61 DGYEDEINEE N

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 18.958607
Match: PF00442
Description: No description for PF00442 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.40860698445222 bayes_pls_golite062009
protein binding 0.38968855779244 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [406-718]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGYHGYVAR AFSDLVQKLF QNRMSIMQRN AAFPPSMFKS TIGHFNSMFS GYMQQDSQEF  60
   61 LAFLLDSLHE DLNRIIKKEY TEKPSLSPGD DVNDWNVVKK LADDTWEMHL KRNCSVITDL 120
  121 FVGMYKSTLY CPECQNVSIT FDPYNDVTLP LPVDTVWDKT IKIFPMNSPP LLLEVELSKS 180
  181 STYMDLKNYV GKMSGLDPNT LFGCEIFSNQ IYVNYESTES NAQFLTLQEL IKPADDVIFY 240
  241 ELPVTNDNEV IVPVLNTRIE KGYKNAMLFG VPFFITLKED ELNNPGAIRM KLQNRFVHLS 300
  301 GGYIPFPEPV GNR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [719-911]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDFADAFPLL VEKYPDVEFE QYKDILQYTS IKVTDKDKSF FSIKILSVEK EQQFASNNRT  60
   61 GPNFWTPISQ LNLDKATDID DKLEDVVKDI YNYSSLVDCA EGVLMQVDDE GDTEGSEAKN 120
  121 FSKPFQSGDD EENKETVTNN ENVNNTNDRD EDMELTDDVE EDASTEPELT DKPEALDKIK 180
  181 DSLTSTPFAI LSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [912-1035]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDIIVCEWSE LGSNEAFSDD KIYNWENPAT LPNKELENAK LERSNAKERT ITLDDCLQLF  60
   61 SKPEILGLTD SWYCPTCKEH RQATKQIQLW NTPDILLIHL KRFESQRSFS DKIDATVNFP 120
  121 ITDL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.356 0.093 ubiquitin-specific protease activity d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.264 0.092 ubiquitin-specific protease activity d.38.1 Thioesterase/thiol ester dehydrase-isomerase
View Download 0.504 0.055 ubiquitin-specific protease activity b.61.1 Avidin/streptavidin
View Download 0.230 N/A N/A b.115.1 Fucose-binding lectin II (PA-IIL)

Predicted Domain #7
Region A:
Residues: [1036-1171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSRYVVYKD DPRGLIYDLY AVDNHYGGLG GGHYTAYVKN FADNKWYYFD DSRVTETAPE  60
   61 NSIAGSAYLL FYIRRHKDGN GLGSSKLQEI IQKSRHGYDE RIKKIYDEQM KLYEFNKTDE 120
  121 EEDVSDDMIE CNEDVQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 25.721246
Match: PF00443
Description: Ubiquitin carboxyl-terminal hydrolase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.540 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.516 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.452 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.442 N/A N/A a.74.1 Cyclin-like
View Download 0.418 N/A N/A a.23.4 Mitochondrial import receptor subunit Tom20

Predicted Domain #8
Region A:
Residues: [1172-1254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APEYSNRSLE VGHIETQDCN DEDDNDDGER TNSGRRKLRL LKKVYKNNSG LGSSSTSEIS  60
   61 EGCPENEVAD LNLKNGVTLE SPE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.442 a.74.1 Cyclin-like
View Download 0.452 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.540 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.516 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.418 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.418 a.42.1 MDM2
View Download 0.369 a.74.1 Cyclin-like
View Download 0.366 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.354 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.347 a.77.1 DEATH domain
View Download 0.323 a.26.1 4-helical cytokines
View Download 0.313 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.307 a.81.1 N-terminal domain of DnaB helicase
View Download 0.290 a.74.1 Cyclin-like
View Download 0.281 a.60.1 SAM/Pointed domain
View Download 0.271 a.64.1 Saposin
View Download 0.264 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.256 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.250 d.137.1 Monooxygenase (hydroxylase) regulatory protein
View Download 0.242 d.8.1 Urease, gamma-subunit
View Download 0.233 c.3.1 FAD/NAD(P)-binding domain
View Download 0.228 a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.221 a.159.2 FF domain
View Download 0.220 a.74.1 Cyclin-like
View Download 0.208 a.118.8 TPR-like
View Download 0.206 d.211.1 Ankyrin repeat
View Download 0.203 a.50.1 Anaphylotoxins (complement system)


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