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View Structure Prediction Details

Protein: YPS7_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 596 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPS7_YEAST.

Description E-value Query
Range
Subject
Range
YPS7 - Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YPS7_YEAST - Aspartic proteinase yapsin-7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPS7 PE=1 S...
0.0 [1..582] [1..582]
gi|6180007 - gi|6180007|gb|AAF05750.1|AF191336_1 pregnancy-associated glycoprotein-11 [Capra hircus]
0.0 [6..442] [31..379]
gi|9581805 - gi|9581805|emb|CAC00543.1| necepsin II [Necator americanus]
0.0 [6..443] [45..415]
gi|28603726, gi|... - gi|6224887|gb|AAF05998.1|AF192332_1 pregnancy-associated glycoprotein-15 [Bos taurus], gi|28603726|r...
0.0 [6..442] [31..379]
asp-4 - aspartyl protease status:Confirmed UniProt:Q21966 protein_id:CAA90633.1
0.0 [5..443] [51..413]
CATD_CHICK - Cathepsin D OS=Gallus gallus GN=CTSD PE=1 SV=1
0.0 [48..441] [70..396]
CATD_CLUHA - Cathepsin D OS=Clupea harengus GN=ctsd PE=1 SV=1
0.0 [1..442] [1..395]

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Predicted Domain #1
Region A:
Residues: [1-56]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTCLILWYLW LISTFQLEFA TASTANTTTT AKSGTSSSTE EPFPVLAVGK DGRGNY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [227-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESSSYSLWLA GDTSTYKTYR DPISNCGKLL LGGVDPSLFT GTLGKFDLIP YVDPVSNAVS  60
   61 VGYPIVPLGP IYIVSNSGQS LNMTSKDFLS PALLDSTSSV SYLPTSTIIQ IAVQIAATYV 120
  121 ESLDRWLVQC SIADMGVSLG FRLRELTIEI PLRDLLSSTY DTSTNSSMFF SSGQEACFLT 180
  181 LYANTNTGVN ILGEAFIKNI YMAMDLEDNT IAIAQAKKVE DDAVTEETNE TTASTIIKKI 240
  241 KSGYIPYAKV MNSSNTRNLT LYPSYRSGYM FTVPGQLTAA YSNGVITG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 150.491979
Match: 1j71A_
Description: Acid protease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 2.20821737779692 bayes_pls_golite062009
endopeptidase activity 2.15355609364204 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.06475762129734 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
hydrolase activity 1.39298582879132 bayes_pls_golite062009
aspartic-type endopeptidase activity 1.26508476841498 bayes_pls_golite062009
aspartic-type peptidase activity 1.26508476841498 bayes_pls_golite062009
binding 0.507703606557062 bayes_pls_golite062009
protein binding 0.177729352622294 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [57-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVNSTFGTPG QRQRLLVDII QPYINLVSGT SESHNEYSGV YHKHPSYLMN DSTSSVPVSP  60
   61 GQIYEISFID GRAVNCTLVT DDMNFTNVSS ENSSTALITD LMVTRDNVQF NSGSLSISNV 120
  121 SFFDIQSSNF KTSGLLGLSG KVTNPGNAID SSQYTEQSYF LSLLKDADII 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 150.491979
Match: 1j71A_
Description: Acid protease
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [515-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGRSFYDTSR ASTSARPSST QFDSFSVSAS EEWSNSTNRT SSASGAGVRL SSPYTFNKDP  60
   61 AGHVTRIASL LLLSIFSILI VL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle