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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process by which a cell uses calcium ions to convert an extracellular signal into a response. A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response. A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert an extracellular signal into a response. A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin. Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway. Any process that modulates the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway. Any process that stops, prevents or reduces the frequency, rate or extent of calcium-mediated signaling.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of calcineurin-NFAT signaling pathway
Acc: GO:0070885
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway.
Synonyms:
  • inhibition of calcineurin-NFAT signaling pathway
  • down-regulation of calcineurin-NFAT signaling pathway
  • downregulation of calcineurin-NFAT signaling pathway
  • negative regulation of calcineurin-NFAT signaling pathway
  • down regulation of calcineurin-NFAT signaling pathway
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070885 - negative regulation of calcineurin-NFAT signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle