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The process whereby the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell. The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell. The process whereby a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate. The process whose specific outcome is the progression of the lymphatic vasculature over time, from its formation to the mature structure. The process whereby a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lymphatic endothelial cell fate commitment
Acc: GO:0060838
Aspect: Biological Process
Desc: The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0060838 - lymphatic endothelial cell fate commitment (interactive image map)
YRC Informatics Platform - Version 3.0
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