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Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: cholate-CoA ligase activity
Acc: GO:0047747
Aspect: Molecular Function
Desc: Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA.
Synonyms:
  • bile acid CoA ligase activity
  • 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity
  • 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity
  • BAL activity
  • cholyl-CoA synthetase activity
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity
  • 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity
  • bile acid coenzyme A ligase activity
  • choloyl-CoA synthetase activity
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity
  • cholate thiokinase activity
  • cholic thiokinase activity
  • 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity
  • cholic acid:CoA ligase activity
  • 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity
  • 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity
  • cholate:CoA ligase (AMP-forming)
  • THCA-CoA ligase activity
  • GO:0047477
  • trihydroxycoprostanoyl-CoA synthetase activity
  • choloyl coenzyme A synthetase activity
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047747 - cholate-CoA ligase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle