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Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling. The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. Any process that modulates the frequency, rate, or extent of tissue remodeling. The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. Any process that stops, prevents or reduces the frequency, rate, or extent of tissue remodeling. Any process that stops, prevents or reduces the frequency, rate or extent of bone resorption.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of bone remodeling
Acc: GO:0046851
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling.
Synonyms:
  • down-regulation of bone remodeling
  • downregulation of bone remodeling
  • inhibition of bone remodeling
  • down regulation of bone remodeling
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 25 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046851 - negative regulation of bone remodeling (interactive image map)
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