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Any process that modulates the rate or extent of progress through the mitotic cell cycle. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. Any process that modulates the frequency, rate or extent of mitosis. A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle. The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis. Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation. Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of mitotic centrosome separation
Acc: GO:0046603
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation.
Synonyms:
  • inhibition of mitotic centrosome separation
  • down regulation of mitotic centrosome separation
  • downregulation of mitotic centrosome separation
  • down-regulation of mitotic centrosome separation
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046603 - negative regulation of mitotic centrosome separation (interactive image map)
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