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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptosis in a wide variety of cells. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Any process that modulates the frequency, rate, or extent of TRAIL production. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of TRAIL biosynthetic process
Acc: GO:0045555
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand.
Synonyms:
  • down-regulation of TRAIL biosynthetic process
  • down regulation of TRAIL biosynthetic process
  • downregulation of TRAIL biosynthetic process
  • inhibition of TRAIL biosynthetic process
  • negative regulation of TRAIL formation
  • negative regulation of TRAIL synthesis
  • negative regulation of TRAIL anabolism
  • negative regulation of TRAIL biosynthesis
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045555 - negative regulation of TRAIL biosynthetic process (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle