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Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes the alkylated base 7-methylguanine.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA-7-methylguanine glycosylase activity
Acc: GO:0043916
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of alkylated DNA; recognizes and removes the alkylated base 7-methylguanine.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043916 - DNA-7-methylguanine glycosylase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle