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The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. The process whereby a precursor cell type acquires the specialized features of an alpha-beta T cell. The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell. The process by which a lymphoid progenitor cell becomes committed to becoming any type of T cell. The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: CD8-positive, alpha-beta T cell lineage commitment
Acc: GO:0043375
Aspect: Biological Process
Desc: The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.
Synonyms:
  • CD8-positive, alpha-beta T-lymphocyte lineage commitment
  • CD8-positive, alpha-beta T cell fate commitment
  • CD8-positive, alpha-beta T-cell lineage commitment
  • CD8-positive, alpha-beta T lymphocyte lineage commitment
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043375 - CD8-positive, alpha-beta T cell lineage commitment (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle