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The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. Any process that modulates the frequency, rate or extent of T cell activation. Any process that stops, prevents, or reduces the rate of leukocyte degranulation. Any process that modulates the frequency, rate, or extent of leukocyte degranulation. Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation. Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. The regulated exocytosis of secretory granules by a leukocyte. Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. Any process that stops, prevents or reduces the frequency, rate or extent of exocytosis. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation. The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of cytotoxic T cell degranulation
Acc: GO:0043318
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.
Synonyms:
  • inhibition of cytotoxic T cell degranulation
  • negative regulation of cytotoxic T-lymphocyte granule exocytosis
  • negative regulation of cytotoxic T lymphocyte degranulation
  • down regulation of cytotoxic T cell degranulation
  • down-regulation of cytotoxic T cell degranulation
  • negative regulation of cytotoxic T-cell granule exocytosis
  • negative regulation of cytotoxic T cell granule exocytosis
  • negative regulation of cytotoxic T-lymphocyte degranulation
  • downregulation of cytotoxic T cell degranulation
  • negative regulation of cytotoxic T lymphocyte granule exocytosis
  • negative regulation of cytotoxic T-cell degranulation
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043318 - negative regulation of cytotoxic T cell degranulation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle