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The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: tumor necrosis factor biosynthetic process
Acc: GO:0042533
Aspect: Biological Process
Desc: The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
Synonyms:
  • TNF alpha biosynthesis
  • tumor necrosis factor synthesis
  • TNF-alpha biosynthesis
  • Tumor Necrosis Factor alpha biosynthesis
  • TNF-alpha biosynthetic process
  • TNF biosynthesis
  • TNF alpha biosynthetic process
  • TNF biosynthetic process
  • tumor necrosis factor formation
  • tumor necrosis factor biosynthesis
  • Tumor Necrosis Factor alpha biosynthetic process
  • tumor necrosis factor anabolism
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 22 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042533 - tumor necrosis factor biosynthetic process (interactive image map)
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Created and Maintained by: Michael Riffle