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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits. A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: monopolin complex
Acc: GO:0033551
Aspect: Cellular Component
Desc: A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits.
Synonyms:
  • Pcs1/Mde4 complex
  • monopolin subcomplex Csm1/Lrs4
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0033551 - monopolin complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle