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Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein-disulfide reductase (glutathione) activity
Acc: GO:0019153
Aspect: Molecular Function
Desc: Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol.
Synonyms:
  • glutaredoxin reductase
  • glutathione-protein disulfide oxidoreductase activity
  • glutathione:protein-disulfide oxidoreductase activity
  • glutathione-insulin transhydrogenase activity
  • insulin reductase activity
  • protein disulfide reductase (glutathione)
  • reductase, protein disulfide (glutathione)
  • thiol:protein-disulfide oxidoreductase activity
  • protein-disulphide reductase (glutathione) activity
  • protein disulfide transhydrogenase activity
  • protein-disulfide isomerase/oxidoreductase activity
  • glutathione--insulin transhydrogenase activity
  • thiol-protein disulphide oxidoreductase activity
  • protein-disulfide interchange enzyme
  • GSH-insulin transhydrogenase activity
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0019153 - protein-disulfide reductase (glutathione) activity (interactive image map)
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