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Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. Catalysis of the reaction: thiocyanate + H2O = NH3 + carbonyl sulfide.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
Acc: GO:0016815
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN.
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 9 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016815 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles (interactive image map)
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