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The process by which glial cells are generated. This includes the production of glial progenitors and their differentiation into mature glia. The process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system. Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. Any process that stops, prevents or reduces the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell. Any process that modulates the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: microglia differentiation
Acc: GO:0014004
Aspect: Biological Process
Desc: The process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system.
Synonyms:
  • microglial cell differentiation
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014004 - microglia differentiation (interactive image map)
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