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The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other. The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa. The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals. The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: immunoglobulin transcytosis in epithelial cells
Acc: GO:0002414
Aspect: Biological Process
Desc: The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 0


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002414 - immunoglobulin transcytosis in epithelial cells (interactive image map)
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