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The process whereby immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent. The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The process whereby a precursor cell type acquires the specialized features of a B cell. The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. The process whereby a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments. The process whereby a precursor cell type acquires the specialized features of an immature B cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: immature B cell differentiation
Acc: GO:0002327
Aspect: Biological Process
Desc: The process whereby a precursor cell type acquires the specialized features of an immature B cell.
Synonyms:
  • immature B-lymphocyte differentiation
  • immature B lymphocyte differentiation
  • immature B-cell differentiation
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002327 - immature B cell differentiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle