Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe

Mol Microbiol. 1998 Sep;29(6):1357-67. doi: 10.1046/j.1365-2958.1998.01009.x.

Abstract

The Schizosaccharomyces pombe cwg2+ gene encodes the beta-subunit of geranylgeranyl transferase I (GGTase I), which participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. Using the two-hybrid system, we have identified the cwp1+ gene that encodes the alpha-subunit of the GGTase I. cwp1p interaction with cwg2p was mapped to amino acids 1-244 or 137-294 but was not restricted to amino acids 137-244. The genomic cwp1+ was isolated and sequenced. It has two putative open reading frames of 677 and 218 bp, separated by a 51 bp intron. The predicted amino acid sequence shows significant similarity to GGTase I alpha-subunits from different species. However, complementation of Saccharomyces cerevisiae ram2-1 mutant by overexpressing the cwp1+ gene was not possible. Expression of both cwg2+ and cwp1+ in Escherichia coli allowed 'in vitro' reconstitution of the GGTase I activity. S. pombe cells expressing the mutant enzyme containing the cwg2-1 mutation do not grow at 37 degrees C, but the growth defect can be suppressed by the addition of sorbitol. Actin immunostaining of the cwg2-1 mutant strain grown at 37 degrees C showed an abnormal distribution of actin patches. The cwg2-1 mutation was identified as a guanine to adenine substitution at nucleotide 604 of the coding region, originating the change A202T in the cwg2p. Deletion of the cwg2 gene is lethal; delta cwg2 spores can divide two or three times before losing viability. Most cells have aberrant morphology and septation defects. Overexpression of the rho1G15VC199R double-mutant allele in S. pombe caused loss of polarity but was not lethal and did not render the (1-3)beta-D-glucan synthase activity independent of GTP. Therefore, geranylgeranylation of rho1p is required for the appropriate function of this GTPase.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actins / metabolism
  • Alkyl and Aryl Transferases / chemistry
  • Alkyl and Aryl Transferases / genetics*
  • Alkyl and Aryl Transferases / metabolism*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Fungal / genetics
  • Escherichia coli / genetics
  • GTP-Binding Proteins / metabolism
  • Gene Expression
  • Genes, Fungal
  • Humans
  • Molecular Sequence Data
  • Point Mutation
  • Protein Prenylation
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Schizosaccharomyces / enzymology*
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces pombe Proteins
  • Sequence Homology, Amino Acid
  • Substrate Specificity
  • rho GTP-Binding Proteins*

Substances

  • Actins
  • DNA, Fungal
  • Recombinant Fusion Proteins
  • Schizosaccharomyces pombe Proteins
  • Alkyl and Aryl Transferases
  • geranylgeranyltransferase type-I
  • GTP-Binding Proteins
  • rho GTP-Binding Proteins
  • rho1 protein, S pombe