RIC1, a novel gene required for ribosome synthesis in Saccharomyces cerevisiae

Gene. 1997 Mar 18;187(2):171-8. doi: 10.1016/s0378-1119(96)00740-8.

Abstract

We isolated a temperature-sensitive mutant of Saccharomyces cerevisiae in which transcription both of ribosomal protein genes and of ribosomal RNA is defective at the non-permissive temperature. Temperature-sensitivity for growth is recessive and segregates 2:2. The wild type gene, termed RIC1 (for ribosome control) was cloned by complementation of the temperature-sensitive phenotype from a genomic DNA library based on the CEN plasmid. RIC1 encodes a protein of 1056 amino acid (aa) residues including a putative nuclear localization sequence. Data base searches revealed that RIC1 is a novel gene and predicted aa sequence share some sequence similarity with viral transcriptional regulatory proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA, Fungal
  • Fungal Proteins / genetics*
  • Genes, Fungal
  • Glycoside Hydrolases / metabolism
  • Guanine Nucleotide Exchange Factors
  • Membrane Proteins
  • Molecular Sequence Data
  • Mutation
  • Nuclear Localization Signals
  • Nuclear Proteins / genetics
  • RNA, Ribosomal / biosynthesis
  • Ribosomal Proteins / genetics
  • Ribosomes / metabolism*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Temperature
  • Transcription Factors / genetics*
  • Transcription, Genetic
  • beta-Fructofuranosidase

Substances

  • DNA, Fungal
  • Fungal Proteins
  • Guanine Nucleotide Exchange Factors
  • Membrane Proteins
  • Nuclear Localization Signals
  • Nuclear Proteins
  • RIC1 protein, S cerevisiae
  • RNA, Ribosomal
  • Ribosomal Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Glycoside Hydrolases
  • beta-Fructofuranosidase

Associated data

  • GENBANK/D43895