Abstract
Protein translocation into mitochondria requires the mitochondrial protein Hsp70. This molecular chaperone of the mitochondrial matrix is recruited to the protein import machinery by MIM44, a component associated with the inner membrane of the mitochondria. Formation of the mt-Hsp70/MIM44 complex is regulated by ATP. MIM44 and mt-Hsp 70 interact in a sequential manner with incoming segments of unfolded preproteins and thereby facilitate stepwise vectorial translocation of proteins across the mitochondrial membranes. The complex appears to act as a molecular ratchet which is energetically driven by the hydrolysis of ATP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism
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Base Sequence
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Biological Transport
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Carrier Proteins / metabolism*
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Cross-Linking Reagents
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DNA / chemical synthesis
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HSP70 Heat-Shock Proteins / metabolism*
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Intracellular Membranes / metabolism
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Membrane Proteins / metabolism*
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Mitochondria / metabolism*
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Mitochondrial Membrane Transport Proteins*
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Mitochondrial Precursor Protein Import Complex Proteins
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Molecular Sequence Data
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Mutation
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Protein Precursors / metabolism*
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Recombinant Fusion Proteins
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins*
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Succinimides
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Tetrahydrofolate Dehydrogenase / metabolism
Substances
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Carrier Proteins
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Cross-Linking Reagents
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HSP70 Heat-Shock Proteins
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Membrane Proteins
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Mitochondrial Membrane Transport Proteins
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Mitochondrial Precursor Protein Import Complex Proteins
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Protein Precursors
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Recombinant Fusion Proteins
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Saccharomyces cerevisiae Proteins
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Succinimides
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TIM44 protein, S cerevisiae
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Adenosine Triphosphate
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DNA
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Tetrahydrofolate Dehydrogenase
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disuccinimidyl suberate