Abstract
When thymidylate production is diminished by a mutation affecting dCTP deaminase, Escherichia coli is known to use an alternate pathway involving deoxycytidine as an intermediate. The pathway requires the gene for any of three nucleoside diphosphate kinases (ndk, pykA, or pykF) and the gene for a 5'-nucleotidase (yfbR).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Deoxycytidine / metabolism*
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Escherichia coli / genetics
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Escherichia coli / growth & development
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Escherichia coli / metabolism*
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Genotype
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Kinetics
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Plasmids
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Thymidine Monophosphate / biosynthesis*
Substances
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Deoxycytidine
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Thymidine Monophosphate