Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

J D Vargas; E Culetto; C P Ponting; I Miguel-Aliaga; K E Davies; D B Sattelle

doi:10.1016/s0925-4773(02)00182-x

Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene

Mech Dev. 2002 Sep;117(1-2):289-92. doi: 10.1016/s0925-4773(02)00182-x.

Authors

J D Vargas¹, E Culetto, C P Ponting, I Miguel-Aliaga, K E Davies, D B Sattelle

Affiliation

¹ MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.

PMID: 12204272
DOI: 10.1016/s0925-4773(02)00182-x

Abstract

We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Animals, Genetically Modified
Caenorhabditis elegans / embryology
Caenorhabditis elegans / genetics*
Caenorhabditis elegans / growth & development*
Caenorhabditis elegans Proteins / genetics*
Cloning, Molecular
Gene Expression Regulation, Developmental
Genes, Helminth*
Green Fluorescent Proteins
Luminescent Proteins / genetics
Mice
Molecular Sequence Data
Recombinant Fusion Proteins / genetics
Sequence Homology, Amino Acid

Substances

Caenorhabditis elegans Proteins
Luminescent Proteins
Recombinant Fusion Proteins
Green Fluorescent Proteins