Abstract
Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome sequence has been determined, uncovering the existence of numerous genes encoding proteins of the ATP-binding cassette (ABC) family. Fungal ABC proteins are implicated in a variety of cellular functions, ranging from clinical drug resistance development, pheromone secretion, mitochondrial function, peroxisome biogenesis, translation elongation, stress response to cellular detoxification. Moreover, some yeast ABC proteins are orthologues of human disease genes, which makes yeast an excellent model system to study the molecular mechanisms of ABC protein-mediated disease. This review provides a comprehensive discussion and update on the function and transcriptional regulation of all known ABC genes from yeasts, including those discovered in fungal pathogens.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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ATP Binding Cassette Transporter, Subfamily D, Member 1
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ATP-Binding Cassette Transporters / genetics
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ATP-Binding Cassette Transporters / metabolism*
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Antifungal Agents / metabolism
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DNA-Binding Proteins / genetics
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Drug Resistance, Microbial / genetics
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Gene Expression Regulation, Fungal
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Multidrug Resistance-Associated Proteins
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Peptide Elongation Factors / genetics
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins*
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Schizosaccharomyces / genetics
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Schizosaccharomyces / metabolism
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Trans-Activators / genetics
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Transcription Factors / genetics
Substances
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ABCD1 protein, human
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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ATP Binding Cassette Transporter, Subfamily D, Member 1
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ATP-Binding Cassette Transporters
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Antifungal Agents
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DNA-Binding Proteins
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Fungal Proteins
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Multidrug Resistance-Associated Proteins
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PDR1 protein, S cerevisiae
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PDR3 protein, S cerevisiae
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Peptide Elongation Factors
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Saccharomyces cerevisiae Proteins
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Trans-Activators
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Transcription Factors
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YAP1 protein, S cerevisiae
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YEF3 protein, S cerevisiae