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Protein Overview: BFR1

General Information:
Name(s) found: BFR1 / YOR198C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 470 amino acids

    Gene Ontology:
    Cellular Component: polysome [IDALink to PubMed article]
    ribonucleoprotein complex [IDALink to PubMed article]
    nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    Biological Process: mRNA metabolic process [IPILink to PubMed article]
    regulation of mitosis [IMPLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQQHKFKR PDVSVRDKKL DTLNVQLKKI DTEIGLIRKQ IDQHQVNDTT QQERKKLQDK  60
   61 NKEIIKIQAD LKTRRSNIHD SIKQLDAQIK RKNNQIEEKL GKKAKFSSTA EAKQRINEIE 120
  121 ESIASGDLSL VQEKLLVKEM QSLNKLIKDL VNIEPIRKSV DADKAKINQL KEELNGLNPK 180
  181 DVSNQFEENQ QKLNDIHSKT QGVYDKRQTL FNKRAALYKK RDELYSQIRQ IRADFDNEFK 240
  241 SFRAKLDKER LKREEEQRLS KLLEQKDVDM GKLQEKLTHA KIPAFTYEIG AIENSLLVLD 300
  301 PTYVKPKKNI LPDLSSNALE TKPARKVVAD DLVLVTPKKD DFVNVAPSKS KKYKKKNQQK 360
  361 NTENEQPASI FNKVDGKFTL EPTLIATLAE LDVTVPINSD DVKITVEQLK KKHEELLSKQ 420
  421 EEQTKQNIES VEKEIEKLNL DYSNKEQQVK KELEEKRLKE QEESEKDKEN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR1 HSP60 NHP6A RPL11B RPL4A
    View Details Krogan NJ, et al. (2006) APN2 BFR1 BRX1 BUR2 LOC1 NHP6A PRK1 RIM1 SGV1 SPB1 TMA64 TSR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BFR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..323] PSI-BLAST 19.69897 Heavy meromyosin subfragment
    2 View Details [324..470] MSA 4.078997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle