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Protein Overview: TEP1

General Information:
Name(s) found: TEP1 / YNL128W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 434 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: inositol lipid-mediated signaling [IMPLink to PubMed article]
    ascospore wall assembly [IMPLink to PubMed article]
    phosphoinositide dephosphorylation [IDALink to PubMed article]
    Molecular Function: inositol or phosphatidylinositol phosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN LIVCSYPVNT  60
   61 YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY KDNDLIGIAA KFESKDFEIQ 120
  121 ELRSTLINDG KIPISPIDLE TRTLVEEETN NVICERIGWL DHFPPPFELL EEIVDGIENY 180
  181 LSVSKNRVAV LHCRMGKGRS GMITVAYLMK YLQCPLGEAR LIFMQARFKY GMTNGVTIPS 240
  241 QLRYLRYHEF FITHEKAAQE GISNEAVKFK FKFRLAKMTF LRPSSLITSE SAIVTTKIQH 300
  301 YNDDRNALLT RKVVYSDIMA HECGGNMTFI FGRDYLTLEN DCRIEFTLGT SKSKAASSII 360
  361 SWTSCASCWL NIYLETLMHI IKDDSSPDYF QVERLKRDEM LGTTISWQEL DGFGELSTHG 420
  421 LKLFQALKLE WEII

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ILV2 MLH3 MLP2 TEP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TEP1 DBP1 2 Unpublished Fields Lab Data
    View Screen TEP1 YDL050C 2 Unpublished Fields Lab Data
    View Screen TEP1 APL2 2 Unpublished Fields Lab Data
    View Screen TEP1 APL2 2 Unpublished Fields Lab Data
    View Screen TEP1 OSW2 2 Unpublished Fields Lab Data
    View Screen TEP1 RSA1 2 Unpublished Fields Lab Data
    View Screen TEP1 ORC4 2 Unpublished Fields Lab Data
    View Screen TEP1 APL2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158]
    [176..197]    		 PSI-BLAST 187.69897 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
    2 View Details [159..175]
    [198..324]    		 PSI-BLAST 187.69897 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
    3 View Details [325..434] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle