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Protein Overview: PKP1

General Information:
Name(s) found: PKP1 / YIL042C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 394 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    protein amino acid phosphorylation [IMPLink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]
    kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKIMRSWKC GGMRWAHRQR PSHELLSQLS FDQHYKIRSN IELLIQDYAS KPIAPLNYEY  60
   61 FLQYRPPLTK KEEYMLTIKT INLLLSLTCK RLNAIQRLPY NAVINPHIER TNSLYLKSLQ 120
  121 TLLSIAYPYE LHNPPKIQAK FTELLDDHED AIVVLAKGLQ EIQSCYPKFQ ISQFLNFHLK 180
  181 ERITMKLLVT HYLSLMAQNK GDTNKRMIGI LHRDLPIAQL IKHVSDYVND ICFVKFNTQR 240
  241 TPVLIHPPSQ DITFTCIPPI LEYIMTEVFK NAFEAQIALG KEHMPIEINL LKPDDDELYL 300
  301 RIRDHGGGIT PEVEALMFNY SYSTHTQQSA DSESTDLPGE QINNVSGMGF GLPMCKTYLE 360
  361 LFGGKIDVQS LLGWGTDVYI KLKGPSKTAL LSKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PKP1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] PSI-BLAST 321.218487 Branched-chain alpha-ketoacid dehydrogenase kinase (BCK)
    2 View Details [211..394] PSI-BLAST 321.218487 Branched-chain alpha-ketoacid dehydrogenase kinase (BCK)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle