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Protein Overview: UBC1

General Information:
Name(s) found: UBC1 / YDR177W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: proteasome complex [IPILink to PubMed article]
    Biological Process: spore germination [TASLink to PubMed article]
    vesicle organization [IMPLink to PubMed article]
    protein polyubiquitination [TASLink to PubMed article]
    endocytosis [TASLink to PubMed article]
    ER-associated protein catabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRAKRIMKE IQAVKDDPAA HITLEFVSES DIHHLKGTFL GPPGTPYEGG KFVVDIEVPM  60
   61 EYPFKPPKMQ FDTKVYHPNI SSVTGAICLD ILKNAWSPVI TLKSALISLQ ALLQSPEPND 120
  121 PQDAEVAQHY LRDRESFNKT AALWTRLYAS ETSNGQKGNV EESDLYGIDH DLIDEFESQG 180
  181 FEKDKIVEVL RRLGVKSLDP NDNNTANRII EELLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADK1 UBC1
    View Details Qiu et al. (2008) UBC1 UBC4 UBC5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UBC1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 877.69897 Ubiquitin conjugating enzyme, UBC


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle