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Protein Overview: Taf1-PC

General Information:
Name(s) found: Taf1-PC / FBpp0089420 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene TBP-associated factor 1 is referred to in FlyBase by the symbol Dmel\Taf1 (CG17603, FBgn0010355). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2472611..2481770. It has the cytological map location 84A1. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; histone serine kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription involved in G2/M-phase of mitotic cell cycle; histone acetylation. 28 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; female germline cyst; external compound sense organ; adult segment; adult mesothoracic segment; thoracic segment; compound cell cluster organ; larva; gamete; integumentary plate. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2098 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMESDNSDD EGSIGNGLDL TGILFGNIDS EGRLLQDDDG EGRGGTGFDA ELRENIGSLS  60
   61 KLGLDSMLLE VIDLKEAEPP SDDEEEEDAR PSAVSASEGM SAFDALKAGV KREDGAVKAQ 120
  121 DDAIDYSDIT ELSEDCPRTP PEETSTYDDL EDAIPASKVE AKLTKDDKEL MPPPSAPMRS 180
  181 GSGGGIEEPA KSNDASSPSD DSKSTDSKDA DRKLDTPLAD ILPSKYQNVD VRELFPDFRP 240
  241 QKVLRFSRLF GPGKPTSLPQ IWRHVRKRRR KRNQSRDQKT TNTGGSDSPS DTEEPRKRGF 300
  301 SLHYAAEPTP AECMSDDEDK LLGDFNSEDV RPEGPDNGEN SDQKPKVADW RFGPAQIWYD 360
  361 MLEVPDSGEG FNYGFKTKAA STSSQPQLKD ERRVKSPEDD VEDPSIADDA FLMVSQLHWE 420
  421 DDVVWDGNDI KAKVLQKLNS KTNAAGWLPS SGSRTAGAFS QPGKPSMPVG SGSSKQGSGA 480
  481 SSKKAQQNAQ AKPAEAPDDT WYSLFPVENE ELIYYKWEDE VIWDAQQVSK VPKPKVLTLD 540
  541 PNDENIILGI PDDIDPSKIN KSTGPPPKIK IPHPHVKKSK ILLGKAGVIN VLAEDTPPPP 600
  601 PKSPDRDPFN ISNDTYYTPK TEPTLRLKVG GNLIQHSTPV VELRAPFVPT HMGPMKLRAF 660
  661 HRPPLKKYSH GPMAQSIPHP VFPLLKTIAK KAKQREVERI ASGGGDVFFM RNPEDLSGRD 720
  721 GDIVLAEFCE EHPPLINQVG MCSKIKNYYK RKAEKDSGPQ DFVYGEVAFA HTSPFLGILH 780
  781 PGQCIQAIEN NMYRAPIYPH KMAHNDFLVI RTRNNYWIRS VNSIYTVGQE CPLYEVPGPN 840
  841 SKRANNFTRD FLQVFIYRLF WKSRDNPRRI RMDDIKQAFP AHSESSIRKR LKQCADFKRT 900
  901 GMDSNWWVIK PEFRLPSEEE IRAMVSPEQC CAYFSMIAAE QRLKDAGYGE KFLFAPQEDD 960
  961 DEEAQLKLDD EVKVAPWNTT RAYIQAMRGK CLLQLSGPAD PTGCGEGFSY VRVPNKPTQT1020
 1021 KEEQESQPKR SVTGTDADLR RLPLQRAKEL LRQFKVPEEE IKKLSRWEVI DVVRTLSTEK1080
 1081 AKAGEEGMDK FSRGNRFSIA EHQERYKEEC QRIFDLQNRV LASSEVLSTD EAESSASEES1140
 1141 DLEELGKNLE NMLSNKKTST QLSREREELE RQELLRQLDE EHGGPSGSGG AKGAKGKDDP1200
 1201 GQQMLATNNQ GRILRITRTF RGNDGKEYTR VETVRRQPVI DAYIKIRTTK DEQFIKQFAT1260
 1261 LDEQQKEEMK REKRRIQEQL RRIKRNQERE RLAQLAQNQK LQPGGMPTSL GDPKSSGGHS1320
 1321 HKERDSGYKE VSPSRKKFKL KPDLKLKCGA CGQVGHMRTN KACPLYSGMQ SSLSQSNPSL1380
 1381 ADDFDEQSEK EMTMDDDDLV NVDGTKVTLS SKILKRHGGD DGKRRSGSSS GFTLKVPRDA1440
 1441 MGKKKRRVGG DLHCDYLQRH NKTANRRRTD PVVVLSSILE IIHNELRSMP DVSPFLFPVS1500
 1501 AKKVPDYYRV VTKPMDLQTM REYIRQRRYT SREMFLEDLK QIVDNSLIYN GPQSAYTLAA1560
 1561 QRMFSSCFEL LAEREDKLMR LEKAINPLLD DDDQVALSFI FDKLHSQIKQ LPESWPFLKP1620
 1621 VNKKQVKDYY TVIKRPMDLE TIGKNIEAHR YHSRAEYLAD IELIATNCEQ YNGSDTRYTK1680
 1681 FSKKILEYAQ TQLIEFSEHC GQLENNIAKT QERARENAPE FDEAWGNDDY NFDRGSRASS1740
 1741 PGDDYIDVEG HGGHASSSNS IHRSMGAEAG SSHTAPAVRK PAPPGPGEVK RGRGRPRKQR1800
 1801 DPVEEVKSQN PVKRGRGRPR KDSLASNMSH TQAYFLDEDL QCSTDDEDDD EEEDFQEVSE1860
 1861 DENNAASILD QGERINAPAD AMDGMFDPKN IKTEIDLEAH QMADESMDVD PNYDPSDFLA1920
 1921 MHKQRQSLGE PSSLQGAFTN FLSHEQDDNG PYNPAEASTS AASGADLGMD ASMAMQMAPE1980
 1981 MPVNTMNNGM GIDDDLDISE SDEEDDGSRV RIKKEVFDDG DYALQHQQMG QAASQSQIYM2040
 2041 VDSSNEPTTL DYQQPPQLDF QQVQEMEQLQ HQVMPPMQSE QLQQQQTPQG DNDYAWTF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] PSI-BLAST 22.221849 TAF(II)230 TBP-binding fragment
    2 View Details [136..188] deduced N/A No confident structure predictions are available.
    3 View Details [189..389] MSA 1.02095 View MSA. No confident structure predictions are available.
    4 View Details [390..507] deduced N/A No confident structure predictions are available.
    5 View Details [508..672] deduced N/A No confident structure predictions are available.
    6 View Details [673..882] deduced N/A No confident structure predictions are available.
    7 View Details [883..1313] PSI-BLAST 23.69897 Heavy meromyosin subfragment
    8 View Details [1314..1355] FFAS03 1.13 HIV nucleocapsid
    9 View Details [1356..1428] deduced N/A No confident structure predictions are available.
    10 View Details [1429..1708] PSI-BLAST 45.045757 TAFII250 double bromodomain module
    11 View Details [1709..1913] deduced N/A No confident structure predictions are available.
    12 View Details [1914..2098] MSA 6.238996 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle