Protein Overview: irs-1

General Information:
Name(s) found:	irs-1 / CE06304 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00002152 locus:iars-1 Isoleucine--tRNA ligase, cytoplasmic status:Partially_confirmed UniProt:Q21926 protein_id:CAA94369.1 [WormBase] pir\|\|T24176 hypothetical protein R11A8.6 - Caenorhabditis elegans [NCBI NR] gi\|3879120\|emb\|CAA94369.1\| C. elegans protein R11A8.6, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|2501013\|sp\|Q21926.1\|SYIC_CAEEL RecName: Full=Isoleucyl-tRNA synthetase, cytoplasmic; AltName: Full=Isoleucine--tRNA ligase; Short=IleRS [NCBI NR] gi\|17541896\|ref\|NP_501914.1\| Isoleucyl tRNA Synthetase family member (irs-1) [Caenorhabditis elegans] [NCBI NR] (Q21926) Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) [Swiss-Prot] Isoleucine--tRNA ligase, cytoplasmic OS=Caenorhabditis elegans GN=irs-1 PE=3 SV=1 [Swiss-Prot] [wormpep67.fasta] CE06304 WBGene00002152 locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed SW:Q21926 protein_id:CAA94369.1 [wormpep150.fasta] 06304 WBGene00002152 locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed SW:Q21926 protein_id:CAA94369.1 [wormpep130-phg-ecoli-orf-rand.fasta] isoleucyl tRNA Synthetase (130.0 kD) (irs-1) [Caenorhabditis elegans]gi\|3879120\|emb\|CAA94369.1\| Hypothetical protein R11A8.6 [Caenorhabditis elegans]gi\|7506619\|pir\|\|T24176 hypothetical protein R11A8.6 - Caenorhabditis elegansgi\|2501013\|sp\|Q21926\|SYI_CA [nrdb_11152004_Chlamydomonas] locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed SW:Q21926 protein_id:CAA94369.1 [wormpep115.fasta.reversed] CE06304 locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed SW:Q21926 protein_id:CAA94369.1 [wormpep80.hongbin] CE06304 WBGene00002152 locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed UniProt:SYIC_CAEEL protein_id:CAA94369.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE06304 WBGene00002152 locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed UniProt:SYIC_CAEEL protein_id:CAA94369.1\| [wormORF-contam.fasta] Isoleucyl-tRNA synthetase, cytoplasmic (Isoleucine--tRNA ligase) (IleRS) [nr-271106-contam.fasta] Isoleucyl tRNA Synthetase family member (irs-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein R11A8.6 [Caenorhabditis elegans] [nr-271106-contam.fasta] CE06304 WBGene00002152 locus:irs-1 isoleucyl-tRNA synthetase status:Partially_confirmed UniProt:Q21926 protein_id:CAA94369.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE06304 WBGene00002152 locus:iars-1 isoleucyl-tRNA synthetase status:Partially_confirmed UniProt:Q21926 protein_id:CAA94369.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE06304 WBGene00002152 locus:iars-1 status:Partially_confirmed UniProt:Q21926 protein_id:CAA94369.1 Isoleucine--tRNA ligase, cytoplasmic [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	1141 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA]
Biological Process:	isoleucyl-tRNA aminoacylation [IEA] tRNA aminoacylation for protein translation [IEA] leucyl-tRNA aminoacylation [IEA] valyl-tRNA aminoacylation [IEA] positive regulation of growth rate [IMP] embryonic development ending in birth or egg hatching [IMP] methionyl-tRNA aminoacylation [IEA] gamete generation [IMP] reproduction [IMP] translation [IEA]
Molecular Function:	nucleotide binding [IEA] valine-tRNA ligase activity [IEA] ATP binding [IEA] aminoacyl-tRNA ligase activity [IEA] leucine-tRNA ligase activity [IEA] isoleucine-tRNA ligase activity [IEA] methionine-tRNA ligase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGLSTVPDN INFAREEDKV AQKWQDENTF QRSVELSKDR PHFTFYDGPP FATGLPHYGH  60
   61 MLTSTIKDVV GRWAHQNGHY VERRFGWDTH GLPVEYEIDK TLGISGPQDV MKMGIANYNN 120
  121 ECRKIVMRYS GEWEKTMGRL GRWVDFKHDY KTLYPWFMES VWWAFSELHK KGLVYKGVKV 180
  181 MPFSTACSTP LSNFEAGQNY KDVVDPAVFV GFKLLDCPNR QLVAWTTTPW TLPSNLALVV 240
  241 HPDMLYVVTK DKTTGIEYVV LEERLGELKN DNLEVIEKLA GSQLKDLRYE PLFPYFAYMR 300
  301 EERNAFRVLN DTFVTSDSGT GVVHQAPYFG EIDFQVCVAN GVIAKDQKMI CPVDESGKYT 360
  361 SEVPDYQGVY VKDADKLIIK RLKEMGNLVR QAEVKHSYPF CWRSDTPLLY KAVPSWFINV 420
  421 ETLIPRLLAN NDETYWVPAF VKEKRFANWL RDARDWAVSR NRFWGTPINL WVSEDGEEVV 480
  481 CVGSIAELEE LSGQKITDLH RESVDDVTIP SRSGRGVLKR VSEVFDCWFE SGSMPYAQNH 540
  541 YPFENRKIFE DNFPADFIAE GIDQTRGWFY TLLVLSTALF NKPPFKNLIC NGLVLASDGA 600
  601 KMSKSKKNYP DPMLIVNKYG ADALRLYLIN SPVVRGENLR FREEGVRDLL KDVFLPWFNA 660
  661 YRFFVQNVQA YEHETGNVFD MNVHVASENV MDRWIESFTN SLVAFVRKEM DSYRLYAVVG 720
  721 PLTKFFDTLT NIYIRLNRKR VKGDNGLHEQ HHALAALGRV LILIVRLMAP FTPFFCEYIW 780
  781 LNLKKVIGST EESVHFLMLP KPDESLIDET VERRVEVMRN VIDLVRLVRD REGLAVKYPL 840
  841 KEMIVINRDS QFLEDVKSLE SYILLELNVR KLTVSQDKQK YGITLKAEPN FKILGARLKG 900
  901 EQKKVADYLK NQITESELEK FLLEGKLTVL GHELSSEEVA VSYAAGSDQG HGYKTHSDAK 960
  961 TIVMIDTTED ESLIEEGLCR EVTNRVQRLR KQAKLVSTDT AHVHIVVSPA DSQLAKVVAA1020
 1021 KLNDIVSATG TPIKLGSPPA AAKAPTATSK SAIKDSEVEL WLFAEGDSFD GITVVDGSKK1080
 1081 VRVHVKTEKE HLKGYADLLY HVRSALDLWN GKIALKNVDG SAVHPTVDVT SLVGQTLQLV1140
 1141 R

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-1	hcp1 IP from december2004	Cheeseman, I.M., et al. (2005)
View Run	hcp-2	hcp2 ip from december	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: irs-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: