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Protein Overview: FBpp0311877, Mer-PA

General Information:
Name(s) found: FBpp0311877 [FlyBase]
Mer-PA / FBpp0074523 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=X:complement(19584865..19585668,19585731..19585967,19586065..19586274,19586334..19586990); ID=FBpp0311877; name=Mer-PB; parent=FBgn0086384,FBtr0345992; dbxref=FlyBase:FBpp0311877,FlyBase_Annotation_IDs:CG14228-PB; MD5=085b98f481e7c86c9c352b696a793371; length=635; release=r5.56; species=Dmel; [FlyBase]
  • The gene Merlin is referred to in FlyBase by the symbol Dmel\Mer (CG14228, FBgn0086384). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19584627..19587531. It has the cytological map location 18E1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 15 unique biological process</span> terms, many of which group under: regulation of biological process; regulation of developmental process; transport; endocytic recycling; cell communication; cell-cell signaling; reproductive process in a multicellular organism; response to chemical stimulus; anatomical structure development; regulation of cell growth; olfactory behavior; regulation of cell proliferation; anterior/posterior axis specification; negative regulation of biological process; sensory organ development; negative regulation of cell proliferation; regulation of signal transduction; negative regulation of organ growth; enzyme linked receptor protein signaling pathway; endocytosis; regulation of anatomical structure morphogenesis. 48 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; thoracic segment; peripheral nervous system; external compound sense organ; nervous system; imaginal precursor; morphogenetic furrow; dorsal thoracic disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 635 amino acids

    Gene Ontology:
    Cellular Component: adherens junction [IDA]
    cytoskeleton [IEA]
    cytoplasm [IDA]
    cell cortex [IDA]
    membrane [IDA]
    [NOT]fusome [IDA]
    extrinsic to membrane [IEA]
    plasma membrane [IDA]
    apical plasma membrane [IDA]
    Nebenkern [IDA]
    Biological Process: sperm individualization [IMP]
    negative regulation of cell proliferation [IGI][IMP]
    spermatogenesis [IMP]
    cell-cell signaling [IEP]
    axis specification [IMP]
    decapentaplegic receptor signaling pathway [IGI]
    negative regulation of organ growth [IMP]
    male meiosis cytokinesis [IMP]
    endocytosis [IEP]
    olfactory behavior [IMP]
    regulation of signal transduction [IGI]
    regulation of cell proliferation [IMP]
    regulation of compound eye retinal cell programmed cell death [IMP]
    pole plasm mRNA localization [IMP]
    compound eye photoreceptor cell differentiation [IGI]
    regulation of cell differentiation [IGI]
    regulation of cell growth [IEP]
    endocytic recycling [IGI]
    Molecular Function: protein binding [IPI]
    cytoskeletal protein binding [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPFGSKKNR SLSVRVSTFD SELEFKLEPR ASGQDLFDLV CRTIGLRESW YFGLQYVDTR  60
   61 SNVSWLKMEK RVRDQRVELH ASNNVYVFSF YAKFFPENVS EELIQEITQH LFFLQVKQSI 120
  121 LSMDIYCRPE ASVLLASYAV HVQYGPYDYE TYKDGMLAGG ELLPKGVTDQ YQMTPEMWEE 180
  181 RIKTWYMDHE PMTRDEVEME YLKIAQDLDM YGVNYFPITN KNKTKLWLGV TSVGLNIYDE 240
  241 RDKLTPKTTF QWNEIRHVSF DDKKFTIRLV DAKVSNFIFY SQDLHINKMI LDLCKGNHDL 300
  301 YMRRRKPDTM EIQQMKAQAK EEKQRRQIER KKFIREKKLR EKAEHERYEL EKSMEHLQNE 360
  361 MRMANDALRR SEETKELYFE KSRVNEEQMQ LTECKANHFK TEMDRLRERQ MKIEREKHDL 420
  421 EKKIRDADFY VHQLTVENDK REAETEKLRK ELICAKMAER EATARLLEFL NSGRKSSTDS 480
  481 LLTASSVSHA ANTASSMAAI STPSLITSSS TNDLETAGGA ELTTHSSHYL VQGDNSSGIS 540
  541 DDFEPKEFIL TDNEMEQITN EMERNHLDYL RNSKQVQSQL QTLRSEIAPH KIEENQSNLD 600
  601 ILSEAQIKAG ENKYSTLKKL KSGSTKARVA FFEEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..635] PSI-BLAST 63.30103 No description for 2i1jA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle