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Protein Overview: Sh-PE

General Information:
Name(s) found: Sh-PE / FBpp0088599 [FlyBase]
Description(s) found:
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  • gi|92090610|sp|P08510.3|KCNAS_DROME RecName: Full=Potassium voltage-gated channel protein Shaker; AltName: Full=Protein minisleep [NCBI NR]
  • gi|24642916|ref|NP_728123.1| shaker, isoform E [Drosophila melanogaster] [NCBI NR]
  • gi|22832465|gb|AAF48786.3| shaker, isoform E [Drosophila melanogaster] [NCBI NR]
  • Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 [Swiss-Prot]
  • The gene Shaker is referred to in FlyBase by the symbol Dmel\Sh (CG12348, FBgn0003380). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17823080..17933532. It has the cytological map location 16F3-16F5. There is experimental evidence that it has the molecular function</span>: voltage-gated cation channel activity. There is experimental evidence that it is involved in the biological process</span>: regulation of action potential; regulation of circadian sleep/wake cycle, sleep; detection of visible light; proboscis extension reflex; flight behavior; sleep; axon extension; larval locomotory behavior; regulation of synaptic activity. 66 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: anatomical structure; organ system; nervous system; adult segment; peripheral nervous system; adult; thoracic segment; developing anatomical structure; embryonic neuron; synapse; adult cuticle; external compound sense organ; neuromuscular junction. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • >CG12348-PE translation from_gene[CG12348 Sh FBgn0003380] seq_release:3 mol_weight=74194 cds_boundaries:(X:17,671,689..17,707,491[-]) aa_length:655 transcript_info:[CG12348-RE seq_release:3] gene_info:[gene symbol:Sh synonyms:[CG17860] FBgn0003380 gene [hmr_yeast5_DM3-1_pombe.fasta]
  • CG12348-PE, isoform E [Drosophila melanogaster]gi|24642916|ref|NP_728123.1| CG12348-PE [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(17834760..17835190,17836815..17837005,17839252..17839381,17843954..17844125,17844644..17844797,17845225..17845346,17845448..17845643,17846710..17846806,17847021..17847189,17847256..17847379,17870384..17870565); ID=FBpp008859 [fly-100309-contam.fasta]
  • Potassium voltage-gated channel protein Shaker [nr-271106-contam.fasta]
  • Shaker CG12348-PE, isoform E [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG12348-PE, isoform E [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(17834760..17835190,17836815..17837005,17839252..17839381,17843954..17844125,17844644..17844797,17845225..17845346,17845448..17845643,17846710..17846806,17847021..17847189,17847256..17847379,17870384..17870565); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(17834760..17835190,17836815..17837005,17839252..17839381,17843954..17844125,17844644..17844797,17845225..17845346,17845448..17845643,17846710..17846806,17847021..17847189,17847256..17847379,17870384..17870565); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:complement(17834760..17835190,17836815..17837005,17839252..17839381,17843954..17844125,17844644..17844797,17845225..17845346,17845448..17845643,17846710..17846806,17847021..17847189,17847256..17847379,17870384..17870565); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786,FlyMine:FBpp0088599,modMine:FBpp0088599; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(17976351..17976532,17953223..17953346,17952988..17953156,17952677..17952773,17951415..17951610,17951192..17951313,17950611..17950764,17949921..17950092,17945219..17945348,17942782..17942972,17940727..17941157)); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786,FlyMine:FBpp0088599,modMine:FBpp0088599; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(17976351..17976532,17953223..17953346,17952988..17953156,17952677..17952773,17951415..17951610,17951192..17951313,17950611..17950764,17949921..17950092,17945219..17945348,17942782..17942972,17940727..17941157)); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786,FlyMine:FBpp0088599,modMine:FBpp0088599; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0088599 type=protein; loc=X:complement(join(17976351..17976532,17953223..17953346,17952988..17953156,17952677..17952773,17951415..17951610,17951192..17951313,17950611..17950764,17949921..17950092,17945219..17945348,17942782..17942972,17940727..17941157)); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786,FlyMine:FBpp0088599,modMine:FBpp0088599; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(17976351..17976532,17953223..17953346,17952988..17953156,17952677..17952773,17951415..17951610,17951192..17951313,17950611..17950764,17949921..17950092,17945219..17945348,17942782..17942972,17940727..17941157)); ID=FBpp0088599; name=Sh-PE; parent=FBgn0003380,FBtr0089657; dbxref=FlyBase:FBpp0088599,FlyBase_Annotation_IDs:CG12348-PE,GB_protein:AAF48786.3,REFSEQ:NP_728123,GB_protein:AAF48786,UniProt/Swiss-Prot:P08510,FlyMine:FBpp0088599,modMine:FBpp0088599; MD5=c171ab073ae917bb66f36b0ec1ca536e; length=655; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 655 amino acids

    Gene Ontology:
    Cellular Component: voltage-gated potassium channel complex [IEA][NAS][TAS]
    integral to membrane [IDA][NAS]
    Biological Process: sensory perception of taste [NAS]
    transmembrane transport [IEA]
    regulation of synaptic activity [IMP]
    detection of visible light [IMP]
    larval locomotory behavior [IMP]
    learning or memory [NAS]
    potassium ion transport [IEA][NAS][TAS]
    proboscis extension reflex [IMP]
    axon extension [IMP]
    flight behavior [IMP]
    courtship behavior [NAS][TAS]
    regulation of circadian sleep/wake cycle, sleep [IMP]
    sleep [IMP]
    regulation of action potential [IMP]
    behavioral response to ether [NAS]
    Molecular Function: voltage-gated potassium channel activity [ISS][NAS][TAS]
    protein binding [IEA]
    voltage-gated cation channel activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVAGLYGL GEDRQHRKKQ QQQQQHQKEQ LEQKEEQKKI AERKLQLREQ QLQRNSLDGY  60
   61 GSLPKLSSQD EEGGAGHGFG GGPQHFEPIP HDHDFCERVV INVSGLRFET QLRTLNQFPD 120
  121 TLLGDPARRL RYFDPLRNEY FFDRSRPSFD AILYYYQSGG RLRRPVNVPL DVFSEEIKFY 180
  181 ELGDQAINKF REDEGFIKEE ERPLPDNEKQ RKVWLLFEYP ESSQAARVVA IISVFVILLS 240
  241 IVIFCLETLP EFKHYKVFNT TTNGTKIEED EVPDITDPFF LIETLCIIWF TFELTVRFLA 300
  301 CPNKLNFCRD VMNVIDIIAI IPYFITLATV VAEEEDTLNL PKAPVSPQDK SSNQAMSLAI 360
  361 LRVIRLVRVF RIFKLSRHSK GLQILGRTLK ASMRELGLLI FFLFIGVVLF SSAVYFAEAG 420
  421 SENSFFKSIP DAFWWAVVTM TTVGYGDMTP VGVWGKIVGS LCAIAGVLTI ALPVPVIVSN 480
  481 FNYFYHRETD QEEMQSQNFN HVTSCPYLPG TLGQHMKKSS LSESSSDMMD LDDGVESTPG 540
  541 LTETHPGRSA VAPFLGAQQQ QQQPVASSLS MSIDKQLQHP LQQLTQTQLY QQQQQQQQQQ 600
  601 QNGFKQQQQQ TQQQLQQQQS HTINASAAAA TSGSGSSGLT MRHNNALAVS IETDV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..577] PSI-BLAST 91.0 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [578..655] PSI-BLAST 4.69897 Potassium channel-related protein MthK


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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