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Protein Overview: PEK-PA

General Information:
Name(s) found: PEK-PA / FBpp0078417 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene pancreatic eIF-2Ã?&#142;Ã?± kinase is referred to in FlyBase by the symbol Dmel\PEK (CG2087, FBgn0037327). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1284285..1290472. It has the cytological map location 83A4. There is experimental evidence that it has the molecular function</span>: elongation factor-2 kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of translational initiation in response to stress. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1162 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [NAS]
    endoplasmic reticulum [NAS]
    Biological Process: protein amino acid phosphorylation [IEA][NAS]
    negative regulation of translation [NAS]
    response to unfolded protein [NAS]
    regulation of translational initiation in response to stress [ISS]
    ER overload response [NAS]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [ISS]
    elongation factor-2 kinase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDDLDGIVR HRRRSLSFLQ IVTLTMAGLV AFDPAQVLAG HPTTDSELQT AGSPRPPGLE  60
   61 HCVDQEERRV ARRLLYISTL DGRLSALDIA KSGKLRWSVP TGPGPLISSS IHRLELTNNG 120
  121 QFVRMIPSLS GGIYKFDGDS IDPIPITAEH LLSSSAKFSD DLVISGGKET RSYGVSVRTG 180
  181 QLLYECSLNG CVNSTEEGLA IDDTIREPDE EDQLEDGEQL RDEAGYIVRH DPLLDDVIIV 240
  241 RRQTQTVRAV ESRTGVERWN FSVGQHELDL VRPSECQLQP RDELELAVLD VDIKVVVPEG 300
  301 IICAFSKSEP QTMLWKYKFD HPIVSAWNTN ADDELQPIDL FSSAQWLWDQ DENDTELPNA 360
  361 PQSPPSIYLG MYDKQLYIQE SIRLRQEIMD QTKVYQQLTG DTSLMPRIPW KPISASSKSL 420
  421 VIFRKDQEDP EMIAEGAVAQ GGELVPYDDE NFAVAAQSVL NASEFVNGNG FYFYTTGDLN 480
  481 GPQECSTQNN PTDLPAITAP TSPTNATSEG TEATGNHSVN DDLGFSLDDI DAPVKVVILS 540
  541 LWFWWKEIVV IAFTSAVILN IFMGQRNQRV EREYLVIERH VPVQTAIEAT EASTQALLGP 600
  601 VVPMQRPGNR FSFPPGQANQ RTISESTTHS GEHYTSRFQS DFELMQCLGR GGFGVVFEAK 660
  661 NKLDENRYAI KRITLPNKES SRQRVLREAR TLASCEHHNI VRYFHSWTET PPTGWQEEED 720
  721 RKLLAHELST SIQIETPDDS TMPSLTEQLK EKRQQQLLSW VSDAANSTAC SHDFHLPGES 780
  781 SLKNIREEYD YDEEEDSLIE FRSESQSAAL RAEEEDDTDD DYEEDEEQQG DHEKRHRSSV 840
  841 SIDIHSASFD LKNINYSQHQ LVSNSFQIES VRPKSSGSDD ANDDNKARRK PLTLALAQNH 900
  901 NNNQNGSQPT PSSATILNGT VAKPSKVYLY IQMQLCRKES LRDWLRDNRS ETRAAHIGDI 960
  961 FHQIVDAVDY VHLKGLIHRD LKPSNIFFSQ DGQIKIGDFG LVTDMADIPN LVAKCGDQSG1020
 1021 LPSCARHTQQ VGTHLYMSPE QLLGQHYDYK VDIYSLGLIF FELHVYFSTE MERIKTLRSL1080
 1081 RDGQYPKDFA VNYPQQYDLL QQMLSAQPEQ RPQTKQLKSQ LRNILQLPHL LSEGQSEQAE1140
 1141 LAERARRLSR SRTFSSSSEP HQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..345] PSI-BLAST 11.522879 No description for 2hz6A was found.
    2 View Details [346..500] deduced N/A No confident structure predictions are available.
    3 View Details [501..865] FFAS03 3.37 No description for 2pziA was found.
    4 View Details [866..1162] PSI-BLAST 80.522879 No description for 2gnfA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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