Protein Overview: pbl-PD

General Information:
Name(s) found:	pbl-PD / FBpp0076489 [FlyBase]
Description(s) found: Found 20 descriptions. SHOW ALL	The gene pebble is referred to in FlyBase by the symbol Dmel\pbl (CG8114, FBgn0003041). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:7889214..7905051. It has the cytological map location 66A18-66A19. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; cell cycle; cell division; cell cycle process; organ morphogenesis; cellular component movement; regulation of developmental process; regulation of cell morphogenesis; cell adhesion; regulation of neurogenesis; establishment of protein localization. 40 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: primordium; peripheral nervous system; external compound sense organ; nervous system; germ layer; adult segment; cytoplasmic part; adult mesothoracic segment; embryonic nervous system; actomyosin contractile ring; spindle; rhabdomere; neuroblast NB6-4 of abdomen; cell cycle; late extended germ band embryo. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1240 amino acids
Gene Ontology:
Cellular Component:	nucleus [NAS] intracellular [IEA]
Biological Process:	regulation of cell shape [IMP] regulation of Rho protein signal transduction [IEA] cytokinesis, actomyosin contractile ring assembly [IMP][TAS] mesodermal cell migration [IMP] cytokinesis after meiosis I [IMP] Malpighian tubule morphogenesis [IMP] nervous system development [IMP] cytokinesis [IMP][NAS][TAS] peripheral nervous system development [TAS] cell adhesion [IMP] cytokinesis after meiosis II [IMP] establishment of protein localization [IMP] spindle assembly [IMP] regulation of axonogenesis [IGI] mesoderm migration [IMP]
Molecular Function:	guanyl-nucleotide exchange factor activity [ISS][NAS] Rho guanyl-nucleotide exchange factor activity [IEA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESGEKTAKG RWKLILGPPA LKYAAEMKQT LGQNSRPIYN YAMRGVVTCF TGIRKKDELT  60
   61 KLVNLIHSMG GCIKKDLNTK TTHLICNHSG GEKYQYAKTF RLTVVRPAWV FAAWADRNSL 120
  121 EFDATQENFT KTHRLKAFEG QKICFFGFPV EEHQHMVDVL LENGGVCAEL DDPECSHVVM 180
  181 PNTGAVFTST STSTDTNPST LINPPESQVP GSSSASQAGE EEQRKAEHLE QAEIKKMEYS 240
  241 HAETDNGMSL DIDQEQKENQ GIEDEDDIHF DERLFVEAAD IINHGEDQLP ESDEEDLEEE 300
  301 QKPKVEEVLK EQEVEEDVQA STPKTSKIRT SLKAATPLSS PEMDGIALDF ESTTQNISPI 360
  361 LKAIDECDLE TDDLPPSEND LKRKRESFDN VSLMSVDSFA LPASTKKPKL IRTGSISRTL 420
  421 RRSVSFVAEP LMKTLRPRRS SVADASSFVG SEAADNSICS LASSINLTLN DSIRKPVKEK 480
  481 LRSFCGRITR SSSRRHDRGV DGTPECTTLL DSGFKTPKAP KLRSTATPKT AKRLFGPVSG 540
  541 VVSALTLTNP STPTPNPNPN TNCTATLDVN DTSIHTFAFC AAAVTPAMPP SSSSSSSSPI 600
  601 LSTSIAVHSS VQVIKSPEES TTRRNSPAPI EEPMAMVVDE HTTLTKPEPK NNHTHILKSD 660
  661 WFWYTIQNGY ANEMDYLFGD YLDSITNTPN TDRRDSLPIS FNKRKRKRFS QRIQLEGTPL 720
  721 GSGKRRSSVS DAGLLSVSNS LFDCTTSPDK LESDKLLHAE PEASDATPAK KSMRFNHFMD 780
  781 FYTTESNYVG ILDTILNLFK NKLEELAETN DPLLNKSEIK TIFGNFLPIH EVHQSMLEHL 840
  841 RKLHANWRED CLIGDIIIQH RDELIKAYPP YVNFFEQMKE QLQYCDREYP RFHAFLKINQ 900
  901 TKPECGRQGL QDLMIRPVQR LPSISLLLND ILKHTTSGNA DHGRLEEALK AIKQVTLHIN 960
  961 EDKRRTESRM AIFDIFNDIE GCPAHLVSSN RSFILKCEVN ELSDSLSGRG DSLVLYLFSD1020
 1021 SIELCKRRSK GFNTAKSPST AKTHKHLKLI SLNTIRLVID ISDSPRAFGL LLRGDKEKLY1080
 1081 TFTISDEETD KSVYVKKLCN QIAAHTCRTD ADKLLICRTS QELEVDISDV NVSTLSKAFK1140
 1141 LAAKTRLKVG RAFSFNKTPN KLKRAVSTMM TSPFGSTNSL TPASQLAQMR LASCTNINEV1200
 1201 DDEDCASMRS SSPSTQSEML VVPPLSVQPT RKNKAVVGRI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: pbl-PD

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: