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Protein Overview: Dip3-PA

General Information:
Name(s) found: Dip3-PA / FBpp0085913 [FlyBase]
Description(s) found:
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  • gi|7302670|gb|AAF57750.1| dorsal interacting protein 3 [Drosophila melanogaster] [NCBI NR]
  • gi|24654782|ref|NP_525003.2| dorsal interacting protein 3 [Drosophila melanogaster] [NCBI NR]
  • gi|17945909|gb|AAL49000.1| RE40480p [Drosophila melanogaster] [NCBI NR]
  • The gene Dorsal interacting protein 3 is referred to in FlyBase by the symbol Dmel\Dip3 (CG12767, FBgn0040465). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14016005..14017751. It has the cytological map location 55B7. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: antennal development; negative regulation of compound eye photoreceptor development; negative regulation of eye photoreceptor cell development; regulation of gene-specific transcription. 14 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye; crossvein; eye photoreceptor cell; ommatidium; wing vein. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG12767-PA translation from_gene[CG12767 Dip3 FBgn0040465] seq_release:3 mol_weight=39737 cds_boundaries:(2R:13,192,411..13,193,736[+]) aa_length:348 transcript_info:[CG12767-RA seq_release:3] gene_info:[gene symbol:Dip3 FBgn0040465 gene_boundaries:(2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V8C0) CG12767 protein (RE40480p) [DrosMelano7227.FASTAC.txt]
  • (AE003800) Dip3 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG12767-PA [Drosophila melanogaster]gi|17945909|gb|AAL49000.1| RE40480p [Drosophila melanogaster]gi|24654782|ref|NP_525003.2| CG12767-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(14016182..14016275,14016481..14016606,14016684..14017510); ID=FBpp0085913; name=Dip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_prote [fly-100309-contam.fasta]
  • CG12767-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE40480p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Dorsal interacting protein 3 CG12767-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(14016182..14016275,14016481..14016606,14016684..14017510); ID=FBpp0085913; name=Dip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(14016182..14016275,14016481..14016606,14016684..14017510); ID=FBpp0085913; name=Dip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Dorsal interacting protein 3 OS=Drosophila melanogaster GN=Dip3 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(14016182..14016275,14016481..14016606,14016684..14017510); ID=FBpp0085913; name=Dip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750,FlyMine:FBpp0085913,modMine:FBpp0085913; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Dorsal interacting protein 3 OS=Drosophila melanogaster GN=Dip3 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:join(18128677..18128770,18128976..18129101,18129179..18130005); ID=FBpp0085913; name=Dip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750,FlyMine:FBpp0085913,modMine:FBpp0085913; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(18128677..18128770,18128976..18129101,18129179..18130005); ID=FBpp0085913; name=Dlip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750,FlyMine:FBpp0085913,modMine:FBpp0085913; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Dorsal interacting protein 3 OS=Drosophila melanogaster GN=Dlip3 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0085913 type=protein; loc=2R:join(18128677..18128770,18128976..18129101,18129179..18130005); ID=FBpp0085913; name=Dlip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750,FlyMine:FBpp0085913,modMine:FBpp0085913; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(18128677..18128770,18128976..18129101,18129179..18130005); ID=FBpp0085913; name=Dlip3-PA; parent=FBgn0040465,FBtr0086734; dbxref=GB_protein:AAF57750.1,FlyBase:FBpp0085913,FlyBase_Annotation_IDs:CG12767-PA,REFSEQ:NP_525003,GB_protein:AAF57750,UniProt/TrEMBL:Q7JZD5,FlyMine:FBpp0085913,modMine:FBpp0085913; MD5=82474b90cb348b0c9d5cab9489a7a6de; length=348; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 348 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    nuclear body [IDA]
    Biological Process: negative regulation of eye photoreceptor cell development [IMP]
    regulation of gene-specific transcription [IMP]
    positive regulation of transcription [NAS]
    antennal development [IMP]
    negative regulation of compound eye photoreceptor development [IMP]
    Molecular Function: DNA binding [IEA][NAS]
    transcription factor activity [NAS]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKNGNQDT FPKTEKMQRY YAERETTGPE FDDRLIKLVR ANPAIYDVSH PHYRRNPVRV  60
   61 DIWDRIANEL GASSRFLQTK WKNIRYNYLQ EVKAIETGQA NPNVRKRRFT EDLSFLQNTA 120
  121 QTYNVKKSQS YVAQQNGMGS DNDSNSFLYP DPEHLKIDAS EGYDIIELDN SDDGSNSDDN 180
  181 EIVPELQLVM GESKQQLSLP TTLNGTSSSN HSHEHDQASS PASSPLLTPM VVMGNGYGQE 240
  241 VHLEQQQTQE QKPFKNSSLS NGEVTIEPIY KPAAIRRALP SDFLTNPFKR KATQAPLQTQ 300
  301 VTSSFNDPIE LYCLSLVDTL RSMRRSERER VKFEFANILK DAKYKDES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] FFAS03 0.955 Solution Structure of RSGI RUH-037, a myb DNA-binding domain in human cDNA
    2 View Details [146..259] deduced N/A No confident structure predictions are available.
    3 View Details [260..348] MSA 2.075995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.86538715425734 bayes_pls_golite062009
  • DNA binding
    		•  4.40186699787632 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.98153794570167 bayes_pls_golite062009
  • transcription factor activity
    		•  3.78935192723648 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25454589469681 bayes_pls_golite062009
  • transcription activator activity
    		•  2.92652250400688 bayes_pls_golite062009
  • binding
    		•  2.92574888336072 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.00875399167309 bayes_pls_golite062009
  • protein binding
    		•  1.84594855626241 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.69615348178304 bayes_pls_golite062009
  • transcription factor binding
    		•  1.24678737091956 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.865913662624162 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.691780246385357 bayes_pls_golite062009
  • chromatin binding
    		•  0.65622150362507 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0723215858239072 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle