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Protein Overview: F261_RAT

General Information:
Name(s) found: F261_RAT [Swiss-Prot]
Description(s) found:
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  • pir||KIRTFB 6-phosphofructo-2-kinase (EC 2.7.1.105) / fructose-2, 6-bisphosphate 2-phosphatase (EC 3.1.3.46), hepatic - rat [NCBI NR]
  • gi|56885|emb|CAA68694.1| unnamed protein product [Rattus norvegicus] [NCBI NR]
  • gi|158262673|ref|NP_036753.4| 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [Rattus norvegicus] [NCBI NR]
  • gi|149031341|gb|EDL86339.1| 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|1200133|emb|CAA33607.1| 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase [Rattus norvegicus] [NCBI NR]
  • gi|119751|sp|P07953.3|F261_RAT RecName: Full=6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; AltName: Full=6PF-2-K/Fru-2,6-P2ASE liver isozyme; Includes: RecName: Full=6-phosphofructo-2-kinase; Includes: RecName: Full=Fructose-2,6-bisphosphatase [NCBI NR]
  • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 OS=Rattus norvegicus GN=Pfkfb1 PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):X_random-1996186 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [hmr_yeast5_DM3-1_pombe.fasta]
  • unnamed protein product [Rattus norvegicus]gi|1200133|emb|CAA33607.1| 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase [Rattus norvegicus]gi|66888|pir||KIRTFB 6-phosphofructo-2-kinase (EC 2.7.1.105) / fructose-2, 6-bisphosphate 2-phosphatase (EC 3. [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru-2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase ; Fructose-2,6-bisphosphatase ] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pfkfb1 Isoform 1 of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [rat-ipi-250309-contam.fasta]
  • Isoform 1 of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 OS=Rattus norvegicus GN=Pfkfb1 [011711_HMR.fasta]
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 OS=Rattus norvegicus GN=Pfkfb1 PE=1 SV=3 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 471 amino acids

    Gene Ontology:
    Cellular Component: cytosol [UNKNOWN]
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex [UNKNOWN][IDA][ISS]
    Biological Process: response to insulin stimulus [IEP]
    positive regulation of glucokinase activity [IMP]
    metabolic process [IEA]
    response to glucocorticoid stimulus [IEP]
    response to starvation [IEP]
    fructose 2,6-bisphosphate metabolic process [UNKNOWN][ISS][TAS]
    response to cAMP [IEP]
    intracellular protein kinase cascade [UNKNOWN]
    response to glucagon stimulus [IEP]
    organ regeneration [IEP]
    carbohydrate phosphorylation [IDA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IDA]
    identical protein binding [UNKNOWN][IDA][IPI]
    protein binding [UNKNOWN]
    fructose-6-phosphate binding [IDA]
    fructose-2,6-bisphosphate 2-phosphatase activity [UNKNOWN][IDA][ISS]
    transferase activity [IEA]
    kinase activity [IEA]
    kinase binding [IPI]
    6-phosphofructo-2-kinase activity [IDA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREMGELTQ TRLQKIWIPH SSSSSVLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST  60
   61 KLTRYLNWIG TPTKVFNLGQ YRREAVSYRN YEFFRPDNTE AQLIRKQCAL AALKDVHKYL 120
  121 SREEGHVAVF DATNTTRERR SLILQFAKEH GYKVFFIESI CNDPEIIAEN IKQVKLGSPD 180
  181 YIDCDQEKVL EDFLKRIECY EINYQPLDEE LDSHLSYIKI FDVGTRYMVN RVQDHVQSRT 240
  241 AYYLMNIHVT PRSIYLCRHG ESELNLRGRI GGDSGLSARG KQYAYALANF IRSQGISSLK 300
  301 VWTSHMKRTI QTAEALGVPY EQWKALNEID AGVCEEMTYE EIQEHYPEEF ALRDQDKYRY 360
  361 RYPKGESYED LVQRLEPVIM ELERQENVLV ICHQAVMRCL LAYFLDKSSD ELPYLKCPLH 420
  421 TVLKLTPVAY GCRVESIYLN VEAVNTHRDK PENVDITREA EEALDTVPAH Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle