Protein Overview: SCN8A_MOUSE

General Information:
Name(s) found:	SCN8A_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6755410\|ref\|NP_035453.1\| sodium channel, voltage-gated, type VIII, alpha [Mus musculus] [NCBI NR] gi\|4426569\|gb\|AAD20438.1\| neuronal voltage-gated sodium channel alpha subunit [Mus musculus] [NCBI NR] gi\|34098761\|sp\|Q9WTU3.1\|SCN8A_MOUSE RecName: Full=Sodium channel protein type 8 subunit alpha; AltName: Full=Sodium channel protein type VIII subunit alpha; AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.6 [NCBI NR] Sodium channel protein type 8 subunit alpha OS=Mus musculus GN=Scn8a PE=1 SV=1 [Swiss-Prot] (Q9WTU3) Sodium channel protein type VIII alpha subunit (Voltage-gated sodium channel alpha subunit Nav1.6) [Swiss-Prot] Ensembl_locations(Chr-bp):15-101375935;15-101375935 Neuronal voltage-gated sodium channel alpha subunit [hmr_yeast5_DM3-1_pombe.fasta] sodium channel, voltage-gated, type VIII, alpha polypeptide; motor end-plate disease; degenerating muscle [HMR_022704-rand.fasta] Splice Isoform 1 of Sodium channel protein type VIII alpha subunit [ipi.MOUSE.v3.06.fasta] sodium channel, voltage-gated, type VIII, alpha polypeptide [Mus musculus]gi\|34098761\|sp\|Q9WTU3\|CIN8_MOUSE Sodium channel protein type VIII alpha subunit (Voltage-gated sodium channel alpha subunit Nav1.6)gi\|4426569\|gb\|AAD20438.1\| neuronal voltage-gated [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Splice Isoform 1 of Sodium channel protein type 8 alpha subunit [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_011323) sodium channel, voltage-gated, type VIII, alpha polypeptide [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] sodium channel, voltage-gated, type VIII, alpha [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Tax_Id=10090 Splice Isoform 1 of Sodium channel protein type VIII alpha subunit [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta] Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] neuronal voltage-gated sodium channel alpha subunit [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 SPLICE ISOFORM 1 OF SODIUM CHANNEL PROTEIN TYPE VIII ALPHA SUBUNIT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Scn8a Isoform 1 of Sodium channel protein type 8 subunit alpha [mouse-ipi-250309-contam.fasta] IPI:IPI00337974.1\|SWISS-PROT:Q9WTU3-1\|REFSEQ:NP_035453 Tax_Id=10090 Gene_Symbol=Scn8a Isoform 1 of Sodium channel protein type 8 subunit alpha [ipi.MOUSE.fasta.20090209] Isoform 1 of Sodium channel protein type 8 subunit alpha OS=Mus musculus GN=Scn8a [011711_HMR.fasta] sp\|Q9WTU3\|SCN8A_MOUSE Sodium channel protein type 8 subunit alpha OS=Mus musculus GN=Scn8a PE=1 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1978 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] dendrite [IDA] membrane [IEA] integral to membrane [UNKNOWN] voltage-gated sodium channel complex [UNKNOWN][IC] neuronal cell body [IDA] plasma membrane [UNKNOWN]
Biological Process:	muscle organ development [IMP] sodium ion transport [UNKNOWN][NAS] adult walking behavior [IMP] ion transport [IEA] locomotory behavior [IMP] transmembrane transport [IEA] transport [IEA] regulation of action potential in neuron [UNKNOWN]
Molecular Function:	nucleotide binding [IEA] ion channel activity [IEA] ATP binding [IEA] sodium channel activity [IEA] voltage-gated ion channel activity [IEA] sodium ion binding [UNKNOWN] voltage-gated sodium channel activity [UNKNOWN][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAARVLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED SKPKPNSDLE  60
   61 AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG KTLFRFSATP ALYILSPFNL 120
  121 IRRIAIKILI HSVFSMIIMC TILTNCVFMT FSNPPEWSKN VEYTFTGIYT FESLVKIIAR 180
  181 GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI 240
  241 VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTRGF 300
  301 DWEEYINNKT NFYMVPGMLE PLLCGNSSDA GQCPEGFQCM KAGRNPNYGY TSFDTFSWAF 360
  361 LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA 420
  421 TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA MATSAGTVSE DAIEEEGEDG VGSPRSSSEL 480
  481 SKLSSKSAKE RRNRRKKRKQ KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF 540
  541 SIMNQSLLSI PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS 600
  601 LFIPIRARER RSSYSGYSGY SQCSRSSRIF PSLRRSVKRN STVDCNGVVS LIGPGSHIGR 660
  661 LLPEATTEVE IKKKGPGSLL VSMEQLASYG RKDRINSIMS VVTNTLVEEL EESQRKCPPC 720
  721 WYKFANTFLI WECHPYWIKL KEIVNLIVMD PFVDLAITIC IVLNTLFMAM EHHPMTPQFE 780
  781 HVLAVGNLVF TGIFTAEMFL KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL GLADVEGLSV 840
  841 LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK 900
  901 ECVCKISQEC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM CLIVFMMVMV 960
  961 IGNLVVLNLF LALLLSSFSA DNLAATDDDG EMNNLQISVI RIKKGVAWAK VKVHAFMQAH1020
 1021 FKQREADEVK PLDELYEKKA NCIANHTGVD IHRNGDFQKN GNGTTSGIGS SVEKYIIDED1080
 1081 HMSFINNPNL TVRVPIAVGE SDFENLNTED VSSESDPEGS KDKLDDTSSS EGSTIDIKPE1140
 1141 VEEVPVEQPE EYLDPDACFT EGCVQRFKCC QVNIEEGLGK SWWILRKTCF LIVEHNWFET1200
 1201 FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI FILEMLLKWT AYGFVKFFTN1260
 1261 AWCWLDFLIV AVSLVSLIAN ALGYSELGAI KSLRTLRALR PLRALSRFEG MRVVVNALVG1320
 1321 AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK YHYCFNETSE IRFEIDEVNN KTDCEKLMEG1380
 1381 NNTEIRWKNV KINFDNVGAG YLALLQVATF KGWMDIMYAA VDSRKPDEQP DYEGNIYMYI1440
 1441 YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM KKLGSKKPQK1500
 1501 PIPRPLNKIQ GIVFDFVTQQ AFDIVIMMLI CLNMVTMMVE TDTQSKQMEN ILYWINLVFV1560
 1561 IFFTCECVLK MFALRHYYFT IGWNIFDFVV VILSIVGMFL ADIIEKYFVS PTLFRVIRLA1620
 1621 RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI1680
 1681 DDMFNFETFG NSMICLFQIT TSAGWDGLLL PILNRPPDCS LDKEHPGSGF KGDCGNPSVG1740
 1741 IFFFVSYIII SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW EKFDPDATQF1800
 1801 IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI HCLDILFAFT KRVLGDSGEL1860
 1861 DILRQQMEER FVASNPSKVS YEPITTTLRR KQEEVSAVVL QRAYRGHLAR RGFICRKITS1920
 1921 NKLENGGTHR EKKESTPSTA SLPSYDSVTK PDKEKQQRAE EGRRERAKRQ KEVRESKC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: SCN8A_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: