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Protein Overview: gi|109508500

General Information:
Name(s) found: gi|109508500 [NCBI NR]
Description(s) found:
Found 2 descriptions.
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  • gi|109508500|ref|XP_001066676.1| PREDICTED: similar to NOD2 protein [Rattus norvegicus] [NCBI NR]
    • Organism: Rattus norvegicus
    Length: 1014 amino acids

    Gene Ontology:
    Cellular Component: cytosol [UNKNOWN]
    vesicle [UNKNOWN]
    signalosome [UNKNOWN]
    cell projection [IDA]
    intracellular [IEA]
    plasma membrane [UNKNOWN]
    cell surface [UNKNOWN]
    Biological Process: response to peptidoglycan [UNKNOWN]
    response to muramyl dipeptide [UNKNOWN][IDA]
    positive regulation of cell proliferation [IDA]
    positive regulation of interleukin-1 beta secretion [UNKNOWN]
    microglial cell activation during immune response [IDA]
    immunoglobulin production during immune response [UNKNOWN]
    positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN]
    positive regulation of dendritic cell cytokine production [IDA]
    negative regulation of interleukin-2 production [UNKNOWN]
    response to exogenous dsRNA [UNKNOWN]
    pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity [IDA]
    positive regulation of interleukin-17 production [UNKNOWN]
    positive regulation of tumor necrosis factor production [UNKNOWN]
    negative regulation of interferon-gamma production [UNKNOWN]
    negative regulation of interleukin-18 production [UNKNOWN]
    negative regulation of tumor necrosis factor production [UNKNOWN]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN]
    defense response to Gram-positive bacterium [UNKNOWN]
    macrophage inflammatory protein-1 alpha production [UNKNOWN]
    negative regulation of NF-kappaB transcription factor activity [UNKNOWN]
    regulation of neutrophil chemotaxis [UNKNOWN]
    regulation of apoptosis [IEA]
    positive regulation of MAPKKK cascade [UNKNOWN]
    activation of immune response [UNKNOWN]
    defense response to bacterium [UNKNOWN][IDA]
    cytokine production involved in immune response [UNKNOWN]
    positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria [UNKNOWN]
    positive regulation of interleukin-12 production [UNKNOWN]
    innate immune response in mucosa [UNKNOWN]
    intracellular signaling pathway [UNKNOWN]
    positive regulation of innate immune response [UNKNOWN]
    negative regulation of growth of symbiont in host [UNKNOWN]
    nucleotide-binding oligomerization domain containing 2 signaling pathway [UNKNOWN]
    positive regulation of JNK cascade [UNKNOWN]
    positive regulation of ERK1 and ERK2 cascade [UNKNOWN]
    positive regulation of humoral immune response mediated by circulating immunoglobulin [UNKNOWN]
    detection of muramyl dipeptide [UNKNOWN]
    detection of bacterium [UNKNOWN]
    response to lipopolysaccharide [UNKNOWN]
    negative regulation of toll-like receptor 2 signaling pathway [UNKNOWN]
    negative regulation of interleukin-12 production [UNKNOWN]
    positive regulation of interleukin-6 production [UNKNOWN]
    positive regulation of phagocytosis [UNKNOWN]
    positive regulation of stress-activated MAPK cascade [UNKNOWN]
    Molecular Function: protein kinase binding [UNKNOWN]
    peptidoglycan binding [UNKNOWN]
    protein binding [UNKNOWN][IEA]
    CARD domain binding [UNKNOWN]
    muramyl dipeptide binding [UNKNOWN][IDA]
    enzyme binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSQEDFQAQ RSQLVALLVS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR  60
   61 LLDTVCNKGV WGCQKLFEAV QEAQANSHTF ELQGCWDVHS LHPTRDLQSH RPAIVRRLCS 120
  121 HVEAILELAR DEGFLSQYEC EEIRLPIFTS SQRARRLLDL AAVKANGLAA FLLQHVRKLP 180
  181 ASLSLPYEAA ECQKFTAKLR TMVSAQSRFL STYDGSENLC LEDIYTENTL ELRTEVGTAG 240
  241 ALQKSPATLG LEELFGTHGH LNKDADTILV VGEAGSGKST LLQRLHLLWA SGQNFREFLF 300
  301 IFPFSCRQLQ CMTKPLSLRT LLFEHCCWPD VGQDDVFQFL LDHPDRVLLT FDGLDEFKFR 360
  361 FTDRERHCSP LDPTSVQTLL FNLLQGNLLK NACKVLTSRP DAVSALLRKF VRTECHLKGF 420
  421 SEEGIKLYLR KHHREPGVAD RLIHLIQATS ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP 480
  481 TTSTDMYLLI LQHFLLHASP PDSFPLGLGP GLLQSRLSTL LHLGHLALQG LAMSCYVFSA 540
  541 QQLQAAQVDS EDISLGFLVR AQSVVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK 600
  601 HLFSCGRPGN SLLLRLLPNL CIQGSRVKGG QAALLQKAEP HNLQITAAFL AGLLSQQHRD 660
  661 LLAACQVPER VLLQRQARAR SCLAHSLREH FHSIPPAVPG ETKSMHAMPG FIWLIRSLYE 720
  721 MQEVQLAREA VRRLDIGHLK LTFCRVGPAE CAALAFVLQH LQRPVALQLD HNSVGDVGVE 780
  781 QLLPCLGVCT ALYLRDNNIS DRGARTLVEC ALRCEQLQKL ALFNNKLTDG CASSVAKLLA 840
  841 HKQNFLSLRV GNNHITAAGA EVLAQGLKSN TSLQFLGFWG NSVGDKGSQA LAEVVADHQR 900
  901 LKWLSLVGNN IGSVGAHALA LMLEKNKSLE ELCLGCGAGR RPRRVSVRGR AAEARSLVFL 960
  961 PCLGRLERRR RPSGLSARPL AAPGRRASDV NRGCPPPASR RAPESRDSCT VGLG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle