Protein Overview: FOXO3

General Information:
Name(s) found:	FOXO3 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|8134467\|sp\|O43524.1\|FOXO3_HUMAN RecName: Full=Forkhead box protein O3; AltName: Full=Forkhead in rhabdomyosarcoma-like 1; AltName: Full=AF6q21 protein [NCBI NR] gi\|55959396\|emb\|CAI16405.1\| forkhead box O3 [Homo sapiens] [NCBI NR] gi\|55959296\|emb\|CAI16295.1\| forkhead box O3 [Homo sapiens] [NCBI NR] gi\|46249801\|gb\|AAH68552.1\| Forkhead box O3 [Homo sapiens] [NCBI NR] gi\|4503739\|ref\|NP_001446.1\| forkhead box O3A [Homo sapiens] [NCBI NR] gi\|42519916\|ref\|NP_963853.1\| forkhead box O3A [Homo sapiens] [NCBI NR] gi\|2895494\|gb\|AAC39592.1\| forkhead protein [Homo sapiens] [NCBI NR] gi\|18203785\|gb\|AAH21224.1\| Forkhead box O3 [Homo sapiens] [NCBI NR] gi\|18044233\|gb\|AAH20227.1\| Forkhead box O3 [Homo sapiens] [NCBI NR] gi\|119568759\|gb\|EAW48374.1\| forkhead box O3A, isoform CRA_a [Homo sapiens] [NCBI NR] gi\|119568758\|gb\|EAW48373.1\| forkhead box O3A, isoform CRA_a [Homo sapiens] [NCBI NR] forkhead box O3 [HGNC (HUGO)] (O43524) Forkhead box protein O3A (Forkhead in rhabdomyosarcoma-like 1) (AF6q21 protein) [Swiss-Prot] Forkhead box protein O3 OS=Homo sapiens GN=FOXO3 PE=1 SV=1 [Swiss-Prot] Forkhead box protein O3A [hmr_yeast5_DM3-1_pombe.fasta] forkhead box O3A; forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 [HMR_022704.fasta] forkhead box O3A; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 [Human2242005.fasta] forkhead box O3A [Homo sapiens]gi\|4503739\|ref\|NP_001446.1\| forkhead box O3A [Homo sapiens]gi\|46249801\|gb\|AAH68552.1\| Forkhead box O3A [Homo sapiens]gi\|18044233\|gb\|AAH20227.1\| Forkhead box O3A [Homo sapiens]gi\|18203785\|gb\|AAH21224.1\| Forkhead box O3A [ [nrdb_11152004_Chlamydomonas] Forkhead box protein O3A (Forkhead in rhabdomyosarcoma-like 1) (AF6q21 protein) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Forkhead box protein O3A [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_001455) forkhead box O3A; forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] forkhead box O3A [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] forkhead box O3A; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 [Homo sapiens] [HumanGallus06162005.fasta] forkhead box O3A; forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 [Homo sapiens] [human-NCBI-042104-rand.fasta] Forkhead box protein O3 (Forkhead in rhabdomyosarcoma-like 1) (AF6q21 protein) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] forkhead box O3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Forkhead box O3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] forkhead box O3A, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] forkhead protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 FORKHEAD BOX PROTEIN O3A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Forkhead box protein O3; AltName: Full=Forkhead in rhabdomyosarcoma-like 1; AltName: Full=AF6q21 protein [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=FOXO3 Forkhead box protein O3 [human-ipi-250309-contam.fasta] Forkhead box O3A [Homo sapiens] [nr-271106-contam.fasta] FOXO3A [Homo sapiens] [nr-271106-contam.fasta] IPI:IPI00012856.1\|SWISS-PROT:O43524\|TREMBL:B4DVZ6;Q68DV3\|ENSEMBL:ENSP00000339527;ENSP00000385824\|REFSEQ:NP_001446;NP_963853\|H-INV:HIT000038766\|VEGA:OTTHUMP00000016944 Tax_Id=9606 Gene_Symbol=FOXO3B;FOXO3 Forkhead box protein O3 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=FOXO3 Forkhead box protein O3A ENSG00000118689 IPI00012856 IPI00783193 [drosphohumanreversed.fasta] Tax_Id=9606 Gene_Symbol=FOXO3 Forkhead box protein O3A [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=FOXO3;FOXO3B Forkhead box protein O3 [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta] forkhead box protein O3 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] O43524;O15171;Q5T2I7;Q9BZ04; RecName: Full=Forkhead box protein O3; AltName: Full=Forkhead in rhabdomyosarcoma-like 1; AltName: Full=AF6q21 protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Forkhead box protein O3 OS=Homo sapiens GN=FOXO3 [011711_HMR.fasta] IPI:IPI00012856.1\|SWISS-PROT:O43524\|TREMBL:B4DVZ6;Q68DV3\|ENSEMBL:ENSP00000339527;ENSP00000385824\|REFSEQ:NP_001446;NP_963853\|H-INV:HIT000038766\|VEGA:OTTHUMP00000016944 Tax_Id=9606 Gene_Symbol=FOXO3;FOXO3B Forkhead box protein O3 [ipi.HUMAN.fasta.20100406] GeneSymbol=FOXO3 Synonyms=AF6q21\|DKFZp781A0677\|FKHRL1\|FKHRL1P2\|FOXO2\|FOXO3A\|MGC12739\|MGC31925 forkhead box protein O3 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00012856.1\|SWISS-PROT:O43524\|TREMBL:Q68DV3\|ENSEMBL:ENSP00000339527;ENSP00000385824\|REFSEQ:NP_001446;NP_963853\|H-INV:HIT000038766\|VEGA:OTTHUMP00000016944 Tax_Id=9606 Gene_Symbol=FOXO3 Forkhead box protein O3 [ipi.HUMAN.20110912.fasta] Forkhead box protein O3 GN=FOXO3 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	673 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE  60
   61 EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV LAPGGQDPGS GPATAAGGLS 120
  121 GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC SSRRNAWGNL SYADLITRAI ESSPDKRLTL 180
  181 SQIYEWMVRC VPYFKDKGDS NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG 240
  241 GKSGKAPRRR AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS 300
  301 DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS SASLSPSVSK 360
  361 PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ PSPTGGLMQR SSSFPYTTKG 420
  421 SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT IQENKPATFS SMSHYGNQTL QDLLTSDSLS 480
  481 HSDVMMTQSD PLMSQASTAV SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT 540
  541 QGALGGSRAL SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP 600
  601 VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN VVGLNVGNFT 660
  661 GAKQASSQSW VPG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..95]	deduced	N/A	No confident structure predictions are available.
2	View Details	[96..269]	PSI-BLAST	23.0	Afx (Foxo4)
3	View Details	[270..542]	deduced	N/A	No confident structure predictions are available.
4	View Details	[543..673]	MSA	1.061976	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: FOXO3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: