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Protein Overview: SRP72

General Information:
Name(s) found: SRP72 / YPL210C [SGD]
Description(s) found:
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  • gi|81175196|sp|P38688.2|SRP72_YEAST RecName: Full=Signal recognition particle subunit SRP72; AltName: Full=Signal recognition particle 72 kDa protein homolog [NCBI NR]
  • gi|37362700|ref|NP_015114.2| Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; Srp72p [Saccharomyces cerevisiae] [NCBI NR]
  • Signal recognition particle subunit SRP72 OS=Saccharomyces cerevisiae GN=SRP72 PE=1 SV=2 [Swiss-Prot]
  • SRP72 Signal recognition particle protein [mips]
  • Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [SGD]
  • Chr XVI from 156211-154289, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • SRP72 SGDID:S0006131, Chr XVI from 156211-154289, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • SRP72 SGDID:S000006131, Chr XVI from 156211-154289, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticu [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Signal recognition particle subunit SRP72 (Signal recognition particle 72 kDa protein homolog) [nr-271106-contam.fasta]
  • Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; Srp72p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SRP72 SGDID:S000006131, Chr XVI from 156211-154289, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Signal recognition particle subunit SRP72 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRP72 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SRP72 SGDID:S000006131, Chr XVI from 156212-154290, Genome Release 64-1-1, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [yeast-030211-contam.fasta]
  • SRP72 SGDID:S000006131, Chr XVI from 156212-154290, Genome Release 64-2-1, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [20141208_orf_trans.fasta]
  • YPL210C SGDID:S000006131, Chr XVI from 156212-154290, Genome Release 64-1-1, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 640 amino acids

    Gene Ontology:
    Cellular Component: signal recognition particle, endoplasmic reticulum targeting [IDALink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [ICLink to PubMed article]
    protein targeting to ER [IPILink to PubMed article]
    Molecular Function: signal sequence binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKDNLTNLL SQLNIQLSQD EHSQVEQTCV KLLDSGCENP ADVFRRCLVA VIQQDKYQKA  60
   61 LHYLKKFKHI DDKYGRKFAL EKLYIFYKLN MPDEFNTLYT AIITDDLDTV LKKDIESLRG 120
  121 ILHVRAQYCY KNGLYQEAFK IYQHLASHNE KDQDSQIELS CNERVPLSVA TELMNRSPLV 180
  181 TPMDESSYDL LFNESFIMAS VGKYDKAIEL LEKALQGATN EGYQNDINTI KLQLSFVLQM 240
  241 VGKTAQSKEI LKGLLQELKA DSPFSLICQN NLNAFVDFSK YNTNFNLLLR ELNVEKLNTF 300
  301 NLQTFTHEQW SNIQRNVLFL RLFNNVKIHS QESLLSRTFD KYSKLVDNVT LESYKTQAKK 360
  361 LYHHTTKTIL SGTDGSTIGI LLLTIQLLII EKEWENAIRI GELFLNESWK SSFEKFNDSQ 420
  421 AIVCYILFEL YKIKGRNNSK SVLLKKLGSV RVQLSGKIQE NIPFWKHVGF ELLSMGNAKE 480
  481 SKALLREISN FSKGDADVLV DRVVSSDSLD IAQGIDLVRD IDIDKLIQLG VKPLESSAKR 540
  541 SKNTAVSKVQ KRKVLELKKK RKIKRLEKFL QGRDTSKLPD PERWLPLRDR STYRPKKKQQ 600
  601 GAKQTQGGAM NKKSEQALDI SKKGKPTVNK KPKNKKKGRK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details (MIPS) Mewes HW, et al. (2004) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Krogan NJ, et al. (2006) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
    View Details Gavin AC, et al. (2006) SEC65 SRP14 SRP54 SRP68 SRP72
    View Details Gavin AC, et al. (2002) BEM2 LHP1 SEC65 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Qiu et al. (2008) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SRP72 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..305] PSI-BLAST 11.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [306..491] MSA 2.962996 View MSA. No confident structure predictions are available.
    3 View Details [492..640] MSA 2.563981 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle