Protein Overview: CLB5

General Information:
Name(s) found:	CLB5 / YPR120C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6325377\|ref\|NP_015445.1\| B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; Clb5p [NCBI NR] gi\|449006\|prf\|\|1918268A cyclin [NCBI NR] gi\|396497\|emb\|CAA49893.1\| cyclin [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S31290 cyclin B5 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|231733\|sp\|P30283.1\|CGS5_YEAST RecName: Full=S-phase entry cyclin-5 [NCBI NR] gi\|171239\|gb\|AAA34503.1\| cyclin B5 [Saccharomyces cerevisiae] [NCBI NR] gi\|1066475\|gb\|AAB68061.1\| Clb5p: G1/S-phase cyclin 5 (Swiss Prot. accession number P30283) [Saccharomyces cerevisiae] [NCBI NR] S-phase entry cyclin-5 OS=Saccharomyces cerevisiae GN=CLB5 PE=1 SV=1 [Swiss-Prot] CLB5 Cyclin, B-type [mips] B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase [SGD] (P30283) S-phase entry cyclin 5 [4932.FASTACCERV.txt] Chr XVI from 775178-773871, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XVI from 773872-775179, reverse complement [yeastorf3.fasta] CLB5, Chr XVI from 773872-775179, reverse complement [yeast_orfs2] CLB5 SGDID:S0006324, Chr XVI from 775178-773871, reverse complement, Verified ORF [yeastflysequest.fasta] CLB5 SGDID:S0006324, Chr XVI from 775180-773873, reverse complement, Verified ORF [10112005cervSGD.fasta] Clb5p [Saccharomyces cerevisiae]gi\|1066475\|gb\|AAB68061.1\| Clb5p: G1/S-phase cyclin 5 (Swiss Prot. accession number P30283) [Saccharomyces cerevisiae]gi\|396497\|emb\|CAA49893.1\| cyclin [Saccharomyces cerevisiae]gi\|231733\|sp\|P30283\|CGS5_YEAST S-phase entry [nrdb_11152004_Chlamydomonas] CLB5 SGDID:S000006324, Chr XVI from 775180-773873, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] cyclin [nr-271106-contam.fasta] cyclin [Saccharomyces cerevisiae] [nr-271106-contam.fasta] S-phase entry cyclin-5 [nr-271106-contam.fasta] cyclin B5 [nr-271106-contam.fasta] Clb5p: G1/S-phase cyclin 5 (Swiss Prot. accession number P30283) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; Clb5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CLB5 SGDID:S000006324, Chr XVI from 775180-773873, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase" [yeast-bovrabprots.fasta] [chemostatdb.fasta] S-phase entry cyclin-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLB5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CLB5 SGDID:S000006324, Chr XVI from 775182-773875, Genome Release 64-1-1, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase" [yeast-030211-contam.fasta] CLB5 SGDID:S000006324, Chr XVI from 775182-773875, Genome Release 64-2-1, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YPR120C SGDID:S000006324, Chr XVI from 775182-773875, Genome Release 64-1-1, reverse complement, Verified ORF, "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	435 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	spindle assembly [IGI][IMP] G2/M transition of mitotic cell cycle [IEP][IMP] G1/S transition of mitotic cell cycle [IEP][IMP] positive regulation of DNA replication [IMP] regulation of S phase of mitotic cell cycle [IMP] premeiotic DNA synthesis [IGI][IMP] regulation of cyclin-dependent protein kinase activity [TAS]
Molecular Function:	cyclin-dependent protein kinase regulator activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGENHDHEQS IKRNSMIYNE NERQLCNSNL KILQNKRALS KNDSSSKQQV QDSKPRRALT  60
   61 DVPVNNNPLS QNKRIVAGSK AAKVRREENI RPIVSAVQKR QIYNDRTAAE QEEEEEEEGE 120
  121 DDDAASIVNK KRRIDAEGVS EIVGWQDLDY VEKDDTAMVA EYSAEIFAFL YRRELETLPS 180
  181 HNYLLDKTSK YYLRPSMRTI LVDWLVEVHE KFQCYPETLF LSINLMDRFL AKNKVTMNKL 240
  241 QLLAVTSLFI AAKFEEVNLP KLAEYAYITD GAASKNDIKN AEMFMLTSLE FNIGWPNPLN 300
  301 FLRRISKADD YDPVNRNIGK FILEYAYCCH QFIHLPPSTV SAMAMYIARR MTNRNKNELW 360
  361 NGTLQHYSGG IDPIHDEAFQ SLCIDLVKDI ASSKTHLDSL ILKYKKPRYG SVYFQTFKWC 420
  421 TSEMHSNFQN LFNLK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CDC28 CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3
View Details	Krogan NJ, et al. (2006)		ATE1 CDC28 CKS1 CLB2 CLB3 CLB4 CLB5 SIC1 SKG3
View Details	Ho Y, et al. (2002)		BUR2 CDC28 CKS1 CLB2 CLB3 CLB5 CLN1 HYP2 YDR170W-A YER138C
View Details	Qiu et al. (2008)		CDC28 CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CLB5	FIR1	2	Unpublished Fields Lab Data
View Screen	CLB5	NUP157	2	Unpublished Fields Lab Data
View Screen	CLB5	UBX6	2	Unpublished Fields Lab Data
View Screen	CLB5	MSA2	2	Unpublished Fields Lab Data
View Screen	CLB5	MIH1	2	Unpublished Fields Lab Data
View Screen	CLB5	FUS2	2	Unpublished Fields Lab Data
View Screen	CLB5	STB1	2	Unpublished Fields Lab Data
View Screen	CLB5	MSA1	2	Unpublished Fields Lab Data
View Screen	CLB5	DSE3	2	Unpublished Fields Lab Data
View Screen	CLB5	KAR9	2	Unpublished Fields Lab Data
View Screen	CLB5	CDC28	2	Unpublished Fields Lab Data
View Screen	CLB5	KIN1	2	Unpublished Fields Lab Data
View Screen	CLB5	FIN1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CLB5	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..137]	MSA	2.291994	View MSA. No confident structure predictions are available.
2	View Details	[138..172] [298..435]	PSI-BLAST	295.232149	Cyclin A
3	View Details	[173..297]	PSI-BLAST	295.232149	Cyclin A

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2