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Protein Overview: SKM1

General Information:
Name(s) found: SKM1 / YOL113W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 655 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: cytokinetic cell separation [IMPLink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGVKKEGWI SYKVDGLFSF LWQKRYLVLN DSYLAFYKSD KCNEEPVLSV PLTSITNVSR  60
   61 IQLKQNCFEI LRATDQKENI SPINSYFYES NSKRSIFIST RTERDLHGWL DAIFAKCPLL 120
  121 SGVSSPTNFT HKVHVGFDPK VGNFVGVPDS WAKLLQTSEI TYDDWNRNSK AVIKALQFYE 180
  181 DYNGLDTMQF NDHLNTSLDL KPLKSPTRYI INKRTNSIKR SVSRTLRKGK TDSILPVYQS 240
  241 ELKPFPRPSD DDYKFTNIED NKVREEGRVH VSKESTADSQ TKQLGKKEQK VIQSHLRRHD 300
  301 NNSTFRPHRL APSAPATKNH DSKTKWHKED LLELKNNDDS NEIIMKMKTV AIDVNPRPYF 360
  361 QLVEKAGQGA SGAVYLSKRI KLPQENDPRF LKSHCHRVVG ERVAIKQIRL SEQPKKQLIM 420
  421 NELLVMNDSR QENIVNFLEA YIIDDEELWV IMEYMEGGCL TDILDAVARS NTGEHSSPLN 480
  481 ENQMAYIVKE TCQGLKFLHN KKIIHRDIKS DNILLNSQGL VKITDFGFCV ELTEKRSKRA 540
  541 TMVGTPYWMA PEIVNQKGYD EKVDVWSLGI MLIEMIEGEP PYLNEDPLKA LYLIANNGSP 600
  601 KLRHPESVSK QTKQFLDACL QVNVESRASV RKLLTFEFLS MACSPEQLKV SLKWH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) HMG2 PTC1 SKM1 TPD3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PLM2 SKM1 1 Unpublished Fields Lab Data
    View Screen RRB1 SKM1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SKM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] ORFEUS 11.96 Grp1
    2 View Details [118..206] PSI-BLAST 126.29073 pak1 autoregulatory domain
    3 View Details [207..305] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [306..454] PSI-BLAST 959.0103 pak1
    5 View Details [455..655] PSI-BLAST 959.0103 pak1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle