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Protein Overview: LEM3

General Information:
Name(s) found: LEM3 / YNL323W [SGD]
Description(s) found:
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  • gi|633662|emb|CAA86374.1| NO333 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6324006|ref|NP_014076.1| Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; Lem3p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S55865 probable membrane protein YNL323w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1302438|emb|CAA96254.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1176582|sp|P42838.1|LEM3_YEAST RecName: Full=Alkylphosphocholine resistance protein LEM3; AltName: Full=Ro-sensitive 3; AltName: Full=Brefeldin-A sensitivity protein 3 [NCBI NR]
  • (P42838) Hypothetical 47.4 kDa protein in EGT2-KRE1 intergenic region [Swiss-Prot]
  • Alkylphosphocholine resistance protein LEM3 OS=Saccharomyces cerevisiae GN=LEM3 PE=1 SV=1 [Swiss-Prot]
  • LEM3 Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane [mips]
  • Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane [SGD]
  • Chr XIV from 31943-33187 [yeastorf5.fasta]
  • LEM3, Chr XIV from 31943-33187 [yeast_orfs2]
  • LEM3 SGDID:S0005267, Chr XIV from 31943-33187, Verified ORF [yeastflysequest.fasta]
  • Lem3p [Saccharomyces cerevisiae]gi|1302438|emb|CAA96254.1| unnamed protein product [Saccharomyces cerevisiae]gi|1362348|pir||S55865 probable membrane protein YNL323w - yeast (Saccharomyces cerevisiae)gi|633662|emb|CAA86374.1| NO333 [Saccharomyces cerev [nrdb_11152004_Chlamydomonas]
  • LEM3 SGDID:S000005267, Chr XIV from 31943-33187, Verified ORF, "Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NO333 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Alkylphosphocholine resistance protein LEM3 (Ro-sensitive 3) (Brefeldin-A sensitivity protein 3) [nr-271106-contam.fasta]
  • Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; Lem3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • LEM3 SGDID:S000005267, Chr XIV from 31943-33187, Verified ORF, "Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphoc [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • LEM3 SGDID:S000005267, Chr XIV from 31943-33187, Verified ORF, "Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane" [SGDyeast.20101221.fasta]
  • Alkylphosphocholine resistance protein LEM3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEM3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • LEM3 SGDID:S000005267, Chr XIV from 31944-33188, Genome Release 64-1-1, Verified ORF, "Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane" [yeast-030211-contam.fasta]
  • LEM3 SGDID:S000005267, Chr XIV from 31944-33188, Genome Release 64-2-1, Verified ORF, "Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p" [20141208_orf_trans.fasta]
  • TR3676|c0_g1_i1|g.2615 ORF TR3676|c0_g1_i1|g.2615 TR3676|c0_g1_i1|m.2615 type:complete len:415 (+) TR3676|c0_g1_i1:71-1315(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YNL323W SGDID:S000005267, Chr XIV from 31944-33188, Genome Release 64-1-1, Verified ORF, "Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 414 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    integral to membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: phospholipid translocation [IMPLink to PubMed article]
    cell surface receptor linked signaling pathway [IMPLink to PubMed article]
    Molecular Function: phospholipid-translocating ATPase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNFDLGQVG EVFRRKDKGA IVSGDNPEEE EDVDASEFEE DEVKPVRTKN RRPKEDAFTQ  60
   61 QRLAAINPVL TPRTVLPLYL LIAVVFVIVG GCILAQNSKV DEVTIYYQDC MTNATSSWSD 120
  121 IPSEHWQFVF HKYKTYNTAP QWRFVDDESD DFTKQRGTCQ IRFTTPSDMK NNVYLNYVLE 180
  181 KFAANHRRYV LSFSEDQIRG EDASYETVHD ATGINCKPLS KNADGKIYYP CGLIANSMFN 240
  241 DTFPLQLTNV GDTSNNYSLT NKGINWESDK KRYKKTKYNY TQIAPPPYWE KMYPDGYNET 300
  301 NIPDIQDWEE FQNWMRPGAF DKITKLIRIN KNDTLPAGEY QLDIGLHWPV LEFNGKKGIY 360
  361 LTHGSHLGGR NPFLGIVYLI GGCICAAMAL ILLTFWLFGG RKIADASSLS WNMK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AIM46 GCN1 HXT7 KAP95 LEM3 NMD5 TCP1 YLR326W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LEM3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..414] Pfam 198.0 LEM3 (ligand-effect modulator 3) family / CDC50 family No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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