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Protein Overview: TOF1

General Information:
Name(s) found: TOF1 / YNL273W [SGD]
Description(s) found:
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  • gi|6324056|ref|NP_014126.1| Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the [NCBI NR]
  • pir||S63247 probable membrane protein YNL273w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730639|sp|P53840.1|TOF1_YEAST RecName: Full=Topoisomerase 1-associated factor 1 [NCBI NR]
  • gi|1302338|emb|CAA96181.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Topoisomerase 1-associated factor 1 OS=Saccharomyces cerevisiae GN=TOF1 PE=1 SV=1 [Swiss-Prot]
  • TOF1 Topoisomerase I interacting factor 1 [mips]
  • Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase [SGD]
  • Chr XIV from 122881-126597 [yeastorf3.fasta]
  • (P53840) Hypothetical 141.1 kDa protein in MET2-SEC2 intergenic region [4932.FASTACCERV.txt]
  • TOF1, Chr XIV from 122881-126597 [yeast_orfs2]
  • TOF1 SGDID:S0005217, Chr XIV from 122881-126597, Verified ORF [yeastflysequest.fasta]
  • Protein that interacts with topoisomerase I [Saccharomyces cerevisiae]gi|1302338|emb|CAA96181.1| unnamed protein product [Saccharomyces cerevisiae]gi|1730639|sp|P53840|TOF1_YEAST Topoisomerase 1-associated factor 1gi|2132779|pir||S63247 probable membra [nrdb_11152004_Chlamydomonas]
  • (P53840) Topoisomerase 1-associated factor 1 [cerv4932.FASTAC]
  • TOF1 SGDID:S000005217, Chr XIV from 122883-126599, Verified ORF, "Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap rep [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; Tof1p [Saccha [nr-271106-contam.fasta]
  • Topoisomerase 1-associated factor 1 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TOF1 SGDID:S000005217, Chr XIV from 122883-126599, Verified ORF, "Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Topoisomerase 1-associated factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOF1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TOF1 SGDID:S000005217, Chr XIV from 122883-126599, Genome Release 64-1-1, Verified ORF, "Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase" [yeast-030211-contam.fasta]
  • TOF1 SGDID:S000005217, Chr XIV from 122883-126599, Genome Release 64-2-1, Verified ORF, "Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia" [20141208_orf_trans.fasta]
  • YNL273W SGDID:S000005217, Chr XIV from 122883-126599, Genome Release 64-1-1, Verified ORF, "Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1238 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [IPILink to PubMed article]
    Biological Process: DNA replication checkpoint [IMPLink to PubMed article][IPILink to PubMed article]
    mitotic sister chromatid cohesion [IGILink to PubMed article][IMPLink to PubMed article]
    DNA topological change [IPILink to PubMed article]
    Molecular Function: molecular_function [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADLQQGTT NAADFSLTVL RARIALLATA IGGPDYTSQI DPPPYKLGDD CLACLKDLKR  60
   61 WFKLVDDQQK RWDVAMAVAE YRILTDDLLP ILIDWENKCS LAAKLAKNNP DHEEFRNKAY 120
  121 YDKIALNCLQ LLVLMTWPLI VTEQSSSNQI TLYGELKKHQ LVYKKTILSM ESGKVLRAAI 180
  181 RLALDVIKID RLSRTPRDNM VLKLVLNFFR NVIAIEPGEF TINTKKSMPK KGITSIDTLP 240
  241 PNVSMDDISL NTVISSFHKN KVFGFLLTLT SSLSKEFDQD FINIPLLEIM FYFTKDVNQE 300
  301 LLFPRQFETG THSKVVNKNE SSSANNIVTS AGFELSKLLQ KEHQMRKNVI KHTSARHSRF 360
  361 GGLLSIQTPD KTRLTVSGSQ ALVDEKIALQ KLDDSKKWNK RIIKKHQSVA AEGLPNSLLN 420
  421 SQTGKAIFFT ESNGKHFKEF INNFIDSGFN ILLHSVTNYF TTEQDRMVTL EQVEYLLFFA 480
  481 WFVKYQLLRS KIDNSADIKQ VSEALKEVTF ILVSSLLRSA YDLKNWTVTH AGMIAFNELL 540
  541 NLVSRTKAAQ EEDSTDIEFI VSRLFSDERI QLLSNLPKIG SKYSLQFMKS CIELTHSVLK 600
  601 VLEQYSDDKT LVIEGKSRRQ KKFNISEGDI TKLIEEENVD RDEALDILTS SLRSIEVNFQ 660
  661 KVQANYMTEP VIETYINFLE RFRELEDDSI KKVFSFFHRV FVQAKEQALL FRFDLIILLR 720
  721 EMLSPDGLDR MSRSRKYVSQ FSDYFLARLK KRLKKSPAWF VGLLFPPLHN SEVGFYQRYG 780
  781 EYNVLNNESM YAAPASQFKP IPDEEALPPS ILLDMKYGVL VSTLLDDGKT ELLDQLLKHI 840
  841 THTLDIFKSW LTVNVNAGKE TVNPPNEYFT LTGVLNNDPI FKDKDYRALL LLIGYSIPRK 900
  901 INEPCFLPGT VEVSDLTVSC ELVKKYLSTP FETPNGLPSS SYLLRVRSEK DSFSHNEQDG 960
  961 WEGDDDYDYN DPYIVPDDQI LSKSDAAYFK DLDNNASDKL KGTKFSKGIA RSKKKDKRKR1020
 1021 RKGEAKTNLP MFGDQDDERP QTVRERHGVF SKEFISDSED DEDLMNPIFF ENETYMRWLL1080
 1081 DKNNGQLTED RYIQFAKFAA ERMNNGGVVT GDYTSLFGGS IPSIESIRAT ESSSFAPDKS1140
 1141 LISLASHVAS EMSIFDVNNN NNNQLSDDDV NSESRNSLGS SQPSNSQNMF QSEVYSRKES1200
 1201 TKRSLEASAA DESDEDEEAI RLFGKKSRVV LSQGDSDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSM3 TOF1
    View Details Krogan NJ, et al. (2006) CSM3 ERV2 MPM1 TOF1 ZPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TOF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..639] MSA 4.016874 View MSA. No confident structure predictions are available.
    2 View Details [640..862] MSA 2.013974 View MSA. No confident structure predictions are available.
    3 View Details [863..1238] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle