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Protein Overview: NGL3

General Information:
Name(s) found: NGL3 / YML118W [SGD]
Description(s) found:
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  • gi|6323517|ref|NP_013588.1| Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p; Ngl3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2497064|sp|Q03210.1|NGL3_YEAST RecName: Full=Probable RNA exonuclease NGL3 [NCBI NR]
  • pir||S54066 hypothetical protein YML118w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (Q03210) Hypothetical 57.7 kDa protein in NDI1-ATR1 intergenic region [Swiss-Prot]
  • Probable RNA exonuclease NGL3 OS=Saccharomyces cerevisiae GN=NGL3 PE=1 SV=1 [Swiss-Prot]
  • NGL3 DNase/RNase (putative) [mips]
  • Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p [SGD]
  • NGL3, Chr XIII from 32334-33851 [yeast_orfs2]
  • Chr XIII from 32334-33851 [yeastorf3.fasta]
  • NGL3 SGDID:S0004587, Chr XIII from 32334-33851, Verified ORF [yeastflysequest.fasta]
  • DNase/RNase (putative); CCR4 C-terminal homolog; displays homology to drosophila Angel gene; homolog to ngl1 and ngl2 [Saccharomyces cerevisiae]gi|2497064|sp|Q03210|YML8_YEAST Hypothetical 57.7 kDa protein in NDI1-ATR1 intergenic regiongi|2131829|pir||S [nrdb_11152004_Chlamydomonas]
  • NGL3 SGDID:S000004587, Chr XIII from 32334-33851, Verified ORF, "Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Probable RNA exonuclease NGL3 [nr-271106-contam.fasta]
  • Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p; Ngl3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Probable RNA exonuclease NGL3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NGL3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NGL3 SGDID:S000004587, Chr XIII from 32334-33851, Genome Release 64-1-1, Verified ORF, "Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p" [yeast-030211-contam.fasta]
  • NGL3 SGDID:S000004587, Chr XIII from 32334-33851, Genome Release 64-2-1, Verified ORF, "3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YML118W SGDID:S000004587, Chr XIII from 32334-33851, Genome Release 64-1-1, Verified ORF, "Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: endonuclease activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSQVEGKIS PSQKESSSTS GLVSPSEDGP AHQKIHRDQL SVDQIKKIRE ERAQKRQVRR  60
   61 NSLISQGKDP DFPTPDLQFI ERPFLPINHD NSKGLTPATI QVTQDSLDVK IMTYNTLAQT 120
  121 LIRRDFFPES GPALKWHKRS KVLVHELKKY RPDVVSLQEV DYNELNFWQE NFHKLGFDVI 180
  181 FKRHEGKTHG LLVAWNNKKF QLDNDWMLDY DNILAGNVIS ARTRTKNIAL IISLYFKGIT 240
  241 DSSSRGIIVA NTHLFWHPFG VFERLRQSYL VLQKIQEIKA CSKYNGWHSL LMGDFNTEPE 300
  301 EPPYLAITKR PLILKGPIRA MVECSLAYRY SKKRNGEESD QDDEECDEKS RGEGHSDQPQ 360
  361 NPKPESFTAT KEEKALVNQL VALHNSLHVK GVSLYGIGYG KVHPENANGS HGEPGLSNWA 420
  421 NTWCGLLDYI FYIEGDHNQD TRQKEPLNAF EGNNNVKIIG YLRMPCAQEM PKHSQPFEGE 480
  481 YASDHISLMC QIRLFFGGEK VHSLK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..407] PSI-BLAST 50.0 DNA repair endonuclease Hap1
    2 View Details [408..505] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  1.79712722403488 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • DNA binding
    		•  1.37658575624902 bayes_pls_golite062009
  • nuclease activity
    		•  1.32173587797854 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.27522193028878 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.27444635886918 bayes_pls_golite062009
  • hydrolase activity
    		•  1.26623219005539 bayes_pls_golite062009
  • binding
    		•  1.15309487870289 bayes_pls_golite062009
  • exonuclease activity
    		•  1.00241970456165 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.921825229691632 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.918937034405287 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.483115797781113 bayes_pls_golite062009
  • phosphatase activity
    		•  0.384661571898828 bayes_pls_golite062009
  • protein binding
    		•  0.245431403492424 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.234646673057692 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  0.228910502815798 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.218294880470342 bayes_pls_golite062009
  • transcription activator activity
    		•  0.110687210838864 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0749803326585898 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0509794286384297 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle