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Protein Overview: HSP60

General Information:
Name(s) found: HSP60 / YLR259C [SGD]
Description(s) found:
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  • pir||JQ0157 heat shock protein HSP60 precursor, mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6323288|ref|NP_013360.1| Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosph [NCBI NR]
  • gi|577181|gb|AAB67380.1| Hsp60p: Heat shock protein 60 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|226279|prf||1504305A mitochondrial assembly factor [NCBI NR]
  • gi|171720|gb|AAA34690.1| heat shock protein 60 (HSP60) [NCBI NR]
  • gi|123579|sp|P19882.1|HSP60_YEAST RecName: Full=Heat shock protein 60, mitochondrial; AltName: Full=Stimulator factor I 66 kDa component; AltName: Full=P66; AltName: Full=CPN60; Flags: Precursor [NCBI NR]
  • Heat shock protein 60, mitochondrial OS=Saccharomyces cerevisiae GN=HSP60 PE=1 SV=1 [Swiss-Prot]
  • (P19882) Heat shock protein 60, mitochondrial precursor (Stimulator factor I 66 kDa component) (P66) (CPN60) [Swiss-Prot]
  • HSP60 Heat shock protein - chaperone, mitochondrial [mips]
  • Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated [SGD]
  • HSP60, Chr XII from 663284-665002, reverse complement [yeast_orfs2]
  • Chr XII from 663284-665002, reverse complement [yeastorf3.fasta]
  • Chr XII from 665002-663284, reverse complement [yeastorf5.fasta]
  • HSP60 SGDID:S0004249, Chr XII from 665004-663286, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Hsp60p [Saccharomyces cerevisiae]gi|577181|gb|AAB67380.1| Hsp60p: Heat shock protein 60 [Saccharomyces cerevisiae]gi|83064|pir||JQ0157 heat shock protein HSP60 precursor, mitochondrial - yeast (Saccharomyces cerevisiae)gi|123579|sp|P19882|HS60_YEAST H [nrdb_11152004_Chlamydomonas]
  • HSP60 SGDID:S000004249, Chr XII from 665004-663286, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein ref [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Hsp60p: Heat shock protein 60 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • heat shock protein 60 (HSP60) [nr-271106-contam.fasta]
  • mitochondrial assembly factor [nr-271106-contam.fasta]
  • Heat shock protein 60, mitochondrial precursor (Stimulator factor I 66 kDa component) (P66) (CPN60) [nr-271106-contam.fasta]
  • Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL; Hsp60p [Sacch [nr-271106-contam.fasta]
  • HSP60 SGDID:S000004249, Chr XII from 665004-663286, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated" [yeast-bovrabprots.fasta]
  • HSP60 SGDID:S000004249, Chr XII from 665004-663286, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Heat shock protein 60, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSP60 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HSP60 SGDID:S000004249, Chr XII from 665002-663284, Genome Release 64-1-1, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated" [yeast-030211-contam.fasta]
  • HSP60 SGDID:S000004249, Chr XII from 665002-663284, Genome Release 64-2-1, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated" [20141208_orf_trans.fasta]
  • YLR259C SGDID:S000004249, Chr XII from 665002-663284, Genome Release 64-1-1, reverse complement, Verified ORF, "Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: protein import into mitochondrial matrix [TASLink to PubMed article]
    protein folding [TASLink to PubMed article]
    Molecular Function: single-stranded DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRSSVVRSR ATLRPLLRRA YSSHKELKFG VEGRASLLKG VETLAEAVAA TLGPKGRNVL  60
   61 IEQPFGPPKI TKDGVTVAKS IVLKDKFENM GAKLLQEVAS KTNEAAGDGT TSATVLGRAI 120
  121 FTESVKNVAA GCNPMDLRRG SQVAVEKVIE FLSANKKEIT TSEEIAQVAT ISANGDSHVG 180
  181 KLLASAMEKV GKEGVITIRE GRTLEDELEV TEGMRFDRGF ISPYFITDPK SSKVEFEKPL 240
  241 LLLSEKKISS IQDILPALEI SNQSRRPLLI IAEDVDGEAL AACILNKLRG QVKVCAVKAP 300
  301 GFGDNRKNTI GDIAVLTGGT VFTEELDLKP EQCTIENLGS CDSITVTKED TVILNGSGPK 360
  361 EAIQERIEQI KGSIDITTTN SYEKEKLQER LAKLSGGVAV IRVGGASEVE VGEKKDRYDD 420
  421 ALNATRAAVE EGILPGGGTA LVKASRVLDE VVVDNFDQKL GVDIIRKAIT RPAKQIIENA 480
  481 GEEGSVIIGK LIDEYGDDFA KGYDASKSEY TDMLATGIID PFKVVRSGLV DASGVASLLA 540
  541 TTEVAIVDAP EPPAAAGAGG MPGGMPGMPG MM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASE1 BFR1 HSP60
    View Details Hazbun TR, et al. (2003) HSP60 TAM41
    View Details Krogan NJ, et al. (2006) ALT1 HSP60 YPL247C
    View Details Qiu et al. (2008) HSP60 HSP78

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CHL4 No Comments Cheeseman IM, et al. (2002)
    View Run IPL1 No Comments Cheeseman IM, et al. (2002)
    View Run TAM41 No Comments Hazbun TR, et al. (2003)
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run HIR2 No Comments Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HSP60 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158]
    [429..572]    		 PSI-BLAST 2510.0 GroEL, E domain; GroEL, A domain; GroEL, I domain
    2 View Details [159..428] PSI-BLAST 2510.0 GroEL, E domain; GroEL, A domain; GroEL, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • misfolded protein binding
    		•  2.60932901317399 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  2.08823822762317 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.90846357786961 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.85422470116133 bayes_pls_golite062009
  • protein binding
    		•  1.68543685258552 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.53776996197958 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.650832159017275 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • insulin binding
    		•  0.54263404774246 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.44104272460881 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • cell surface binding
    		•  0.326492680678891 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.280457039468896 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle