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Protein Overview: MGA2

General Information:
Name(s) found: MGA2 / YIR033W [SGD]
Description(s) found:
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  • gi|731921|sp|P40578.1|MGA2_YEAST RecName: Full=Protein MGA2 [NCBI NR]
  • gi|6322224|ref|NP_012299.1| ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [NCBI NR]
  • pir||S48495 probable membrane protein YIR033w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|557839|emb|CAA86193.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Protein MGA2 OS=Saccharomyces cerevisiae GN=MGA2 PE=1 SV=1 [Swiss-Prot]
  • MGA2 May be involved in the remodeling chromatin structure [mips]
  • ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [SGD]
  • MGA2, Chr IX from 416121-419462 [yeast_orfs2]
  • Chr IX from 416121-419462 [yeastorf3.fasta]
  • (P40578) MGA2 protein [4932.FASTACCERV.txt]
  • MGA2 SGDID:S0001472, Chr IX from 416121-419462, Verified ORF [yeastflysequest.fasta]
  • ER membrane protein involved, with its homolog Spt23p, in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • MGA2 SGDID:S000001472, Chr IX from 416121-419462, Verified ORF, "ER membrane protein involved, with its homolog Spt23p, in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent pro [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MGA2 SGDID:S000001472, Chr IX from 416121-419462, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent pro [yeast-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein MGA2 [nr-271106-contam.fasta]
  • ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; Mga2p [Saccharomyces cerev [nr-271106-contam.fasta]
  • MGA2 SGDID:S000001472, Chr IX from 416121-419462, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein MGA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MGA2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MGA2 SGDID:S000001472, Chr IX from 416124-419465, Genome Release 64-1-1, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting" [yeast-030211-contam.fasta]
  • MGA2 SGDID:S000001472, Chr IX from 416124-419465, Genome Release 64-2-1, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YIR033W SGDID:S000001472, Chr IX from 416124-419465, Genome Release 64-1-1, Verified ORF, "ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1113 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    Biological Process: response to cold [IEPLink to PubMed article][IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    fatty acid metabolic process [IMPLink to PubMed article]
    Molecular Function: transcription activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQNSEFLTE TPGSDPHISQ LHANSVMESQ LLDDFLLNGS PMYQDDSMAH INIDEGANFQ  60
   61 NFIKTDEGDS PNLLSFEGIG NNTHVNQNVS TPLEEEMESN RALKEEEEDE HENKVFNEKN 120
  121 IGNPAHDEIV FGRKETIQSV YINPLDYLKV NAAQLPLDVE VSGLPQVSRV ENQLKLKVKI 180
  181 TSETPLNQSM LYLPSDSISR EKFYLKKNIE DFSEDFKKNL LYINAFVLCA VSNRTTNVCT 240
  241 KCVKREQRRA ARRKSGIADN LLWCNNINRR LVVFNNKQVF PIMKTFDNVK EFELTTRLVC 300
  301 YCRHHKANNG FVILFTITDW QNRLLGKFTT TPIMITDRKP ANMDTTKFNN TTTSSRRQLT 360
  361 EEESTTEYYS TDNNQLSKDE NMPFQYTYQH NPYDNDSQMN NIPLKDKNVP FPYSISQQTD 420
  421 LLQNNNLSLN LSLPNQHIPS PTSMSEEGSE SFNYHHRDND NPVRTISLTN IEQQSQLNQR 480
  481 KRARNNLEND IGKPLFKHSF SNSISATNTM NPALHSMQDF SMKNNNNNLP SINRVIPSQG 540
  541 PINGGIEVTL LGCNFKDGLS VKFGSNLALS TQCWSETTIV TYLPPAAYAG QVFVSITDTN 600
  601 NENNNDDLPQ EIEINDNKKA IFTYVDDTDR QLIELALQIV GLKMNGKLED ARNIAKRIVG 660
  661 NDSPDSGTNG NSCSKSTGPS PNQHSMNLNT SVLYSDEVLI QKVIKSLNIN SNISICDSLG 720
  721 RTLLHLACLK NYSSLVYTLI KKGARVNDID SFGLTPLHFA CISGDPKIIK MLLNCKVNYS 780
  781 LRSHNGLTAR EVFIANHIHS KEIDKKQDNR DNHKFVHNDT YISEVLSLFE EFQNGTKFTD 840
  841 SVETDSNYSI SRKYSQSSFN SSLLDNESLN ENLFESQSMI NPTSMEIQHP TLQLFENSSY 900
  901 SEYDQSDFEE DGDEDLFVTD EVEKPGVACR EEQSELLDIG SSANEPEEDN GSTSLWNRVL 960
  961 HRINDDLPKY EDLFPLSWGK DDKLKTTNQD SIVEQSASNI ENSENSEEED YEEEEEFLKK1020
 1021 QFNRFFQNKQ NFRNDKMLIF FWIPLTLLLL TWFIMYKFGN QDSSINHISE LISEYLRIAL1080
 1081 AKFLLGNERM KTAFRSKLSN LQTTRMLNDL IVS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
    View Details Gavin AC, et al. (2002) CAM1 EFB1 FAP1 GFA1 GUS1 ILV1 KAP123 MGA2 NEW1 OLA1 SBP1 SEC27 TEF1, TEF2 TEF4
    View Details Qiu et al. (2008) MGA2 SPT23

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GPI14 MGA2 2 Hazbun TR, et al. (2003)
    View Screen ILM1 MGA2 2 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..346] deduced N/A No confident structure predictions are available.
    2 View Details [347..524] MSA 1.121988 View MSA. No confident structure predictions are available.
    3 View Details [525..682] PSI-BLAST 77.211549 bcl-3
    4 View Details [683..801] PSI-BLAST 77.211549 bcl-3
    5 View Details [802..869] PSI-BLAST 16.045757 No description for 1lnnA_ was found.
    6 View Details [870..980] deduced N/A No confident structure predictions are available.
    7 View Details [981..1059] MSA 1.06699 View MSA. No confident structure predictions are available.
    8 View Details [1060..1113] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.17983095277661 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.77275610412175 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.31270638552607 bayes_pls_golite062009
  • DNA binding
    		•  1.1922382945387 bayes_pls_golite062009
  • transcription activator activity
    		•  1.13308454180419 bayes_pls_golite062009
  • transcription factor activity
    		•  0.72431748142192 bayes_pls_golite062009
  • transcription factor binding
    		•  0.56378250255767 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.443598477652456 bayes_pls_golite062009
  • signal transducer activity
    		•  0.177373330518427 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.177373330518427 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.0844768926216624 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle